Chemicals & Small Molecules

t-Boc-N-MMAF

Biotin-PEG11-NHCO-MMAF-N-t-Boc functions as a biotinylation reagent with the biotin moiety linked to an MMAF payload protected by a Boc group which can be removed under acidic conditions to reveal the free amine. The connecting PEG arm enhances the water-solubility of the compound.

Biotin-PEG11-NHCO-MMAF-N-t-Boc acts as a biotinylation reagent with the biotin moiety linked to an MMAF payload for antibody-drug conjugates (ADCs) via a PEG chain that improves the hydrophilicity of the molecule.

AMCA-PEG8-Mal is a AMCA dye linker containing a maleimide group, which selectively reacts with free thiol, sulfhydryl, or mercapto group via Michael addition to form a stable carbon sulfur bond. The hydrophilic PEG spacer arm increases water solubility as well as membrane permability. This dye is used for protein and peptide labeing. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Exatecan-2-(aminomethoxy)acetamide-Gly-Phe-Gly-Gly-PEG2-endo-BCN represents a tetrapeptide derivative which may be employed in the development of antibody drug conjugates (ADCs). The BCN group is a click chemistry handle which readily reacts with azide groups on a target molecule. Exatecan is a structural analog of camptothecin and shows anticancer activity. The PEG2 spacer imparts hydrophilicity.

DBCO-PEG-2-Val-Cit-PAB-OH constitutes a cleavable ADC linker. The Val-Cit was designed specifically to be cleaved by Cathepsin B. The DBCO moiety engages in copper-free catalyzed click chemistry with azido-bearing moieties.

AMCA-PEG8-Amine, TFA salt is a AMCA dye linker containing an amine group and a hydrophilic PEG spacer arm. The amine group makes the compound more reactive toward carboxylic acids, NHS esters and other carbonyl groups. The hydrophilic PEG spacer arm increases water solubility as well as membrane permability. This dye is used for protein and peptide labeing. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 447 is a novel ionizable lipid featuring two branched tails, a dimethylamine head group, and a biodegradable amide linkage to biotin. This compound has been designed for bioconjugation, protein functionalization applications, or a novel component of lipid nanoparticle formulations. Reagent grade, for research purpose. Please contact us for GMP-grade.

Sulfo DBCO-PEG4-UBQ-2 is a click chemistry reagent combining a dark quencher, UBQ-2, with a polyaromatic-azo backbone, offering no native emission, and a hydrophilic PEG spacer arm. It effectively quenches fluorescence in the 560-670 nm range, ideal for qPCR probes and FRET applications with orange to far-red dyes. The DBCO group facilitates copper-free click chemistry, while the sulfo group enhances water solubility. Reagent grade, for research use only. Please contact us for GMP-grade inquiries.