Chemicals & Small Molecules

ASK8007 is a humanized antibody that blocks bone bridging proteins and can be used to study rheumatoid arthritis.

MSC-1 (Anti-LIF Antibody) is a humanized anti-leukemia inhibitory factor (LIF) monoclonal antibody that acquires anti-tumor and pro-inflammatory functions in a homozygous colon cancer mouse model and can be used to study advanced solid tumors.

KRN330 is a fully human anti-A33 monoclonal antibody that can be used to study advanced rectal cancer.

Ieramilimab (LAG525) is a humanized antibody targeting LAG-3 with potential anticancer activity, blocking its interaction with MHC-II molecules by binding to LAG-3.Pranlukast hemihydrate can be used to study malignant tumors.

Nipocalimab (M281) is a fully humanized anti-FcRn monoclonal antibody that can be used to study systemic myasthenia gravis and rheumatoid arthritis.

Sotigalimab (APX 005) is a monoclonal antibody targeting CD40 with potential antitumor activity and can be used to study metastatic pancreatic cancer and melanoma.

Foravirumab (CR4098) is a monoclonal antibody targeting rabies virus glycoprotein (RABV-G) for the study of infectious diseases such as rabies.

WL47 TFA is a selective small molecule caveolin-1 oligomer disruptor that disrupts CAV1 oligomers.

IGF2BP1-IN-1 (Compound A11), an inhibitor of IGF2BP1, impedes the associated downstream signaling and demonstrates a high affinity for the IGF2BP1 protein with a dissociation constant (K D) of 2.88 nM. The compound effectively halts the proliferation of cancer cells, as evidenced by an IC50 of 9 nM for A549 cells and 34 nM for HCT116 cells, while also inducing apoptosis in these cells. Moreover, IGF2BP1-IN-1 has been shown to inhibit tumor growth in an A549 xenograft mouse model [1].