Chemicals & Small Molecules

BP Lipid 406 is an analog of LP01 featuring an ionizable azetidine head group. This heterocyclic functionality was designed to fine-tune the properties of this popular lipid while maintaining the unsaturated and branched lipid tails, and the biodegradable ester and carbonate linkages. This compound may be used as a novel component in lipid nanoparticle (LNP) formulations. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Mal-C5-Val-Ala-PAB-MMAE is a cleavable ADC linker. The Val-Ala linkers can be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups.

Acid-PEG1-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU). The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Bis-sulfone-PEG1-Bis-sulfone is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.

Gly-Gly-Gly-PEG7-methyltetrazine is a tripeptide featuring three glycine residues. The methyltetrazine can react with TCO-containing compounds without the catalysis of Cu or elevated temperatures. The PEG7 spacer imparts aqueous solubility of the compound.

503O13 is a biodegradable lipid-like compound designed for the delivery of siRNA.

7-O-(Azido-PEG4)- paclitaxel posseses paclitaxel moiety. The azido group is reactive towards BCN, DBCO, alkyne. The hydrophilic PEG spacer makes the compound more compatible in aqueous media.

Val-Cit-PAB-Exatecan is an enzymatically cleavable peptide with an exatecan payload, and it is used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B.

MC-Val-Cit-PAB-Exatecan is a cleavable ADC linker containing a Val-Cit dipeptide, PAB motif, and Exactecan. The Val-Cit was designed to be cleaved specifically by Cathepsin B. MC group is reactive with thiol moiety.