Chemicals & Small Molecules

DBCO-PEG2-Val-Cit-PAB-Exatecan is a cleavable ADC linker. It includs a Cathepsin-cleavable Val-Cit dipeptide, PAB moeity, exatecan payload, and DBCO group; A click chemistry handle that readily reacts with azide groups. The PEG2 chain increases the hydrophilicity of the compound.

BP Fluor 647-PEG-CH2CO2-NHS, MW 2,000

Fmoc-L-Glu(OAll)-Val-Cit-PAB-MMAE functions as an Fmoc-protected tripeptide linker-payload in the employment of antibody drug conjugates (ADCs)

Bis-sulfone-PEG2-Bis-sulfone consists of four sulfone groups which can be conjugated with thiol groups of proteins and a PEG2 spacer for improved water-solubility of the compound.

5-bromopentyl 2-octyldecanoate

DBCO-trimethoxysilane contains DBCO to react with azide-bearing compounds or biomolecules to form a triazole linkage and a triethoxysilane to react with surface-bearing hydroxyl groups, resulting in a substitution reaction at silicon.

L-Glu(OAll)-Val-Cit-PAB-MMAE

DBCO-Val-Cit-PAB-OH represents a precursor of antibody drug conjugates (ADCs). It posseses a chemically labile Val-Cit dipeptide, highly-reactive DBCO group for copper-free click reactions, and a benzylic alcohol that can be used to attach with reactive groups such as PNP for conjugation with drug payloads.

N-(Azido-PEG4)-N-bis(PEG4-Val-Cit-PAB-MMAE) is a dual linker-payload containing an azide handle that is free to perform click chemistry with terminal alkynes or strained cyclooctynes such as DBCO or BCN. The two linker-payloads each include the cathepsin-cleavable Val-Cit-PAB dipeptide ligated to an MMAE payload which is an efficiently released toxin to target cells to cause cellular apoptosis.