Chemicals & Small Molecules

DSPE-PEG5-azide is a PEG linker. The hydrophobic features of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG linker enhances the water solubility of the overall compound allowing for the delivery of the drug. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN.

Acid-PEG4-Val-Cit-PAB-MMAE is a cleavable ADC linker comprised of a carboxylic acid, a hydrophilic PEG spacer, and a chemically labile Val-Cit-PAB dipeptide ligated to an MMAE payload. Carboxylic acids reacts with amines or alcohols while the Val-Cit-PAB motif is an enzyme-cleavable linker. This linker efficiently releases the toxin, MMAE, to target cells to cause cellular apoptosis.

Fmoc-cys(npys)-OH

(2R,3S)-3-(tert-Butoxy)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)butanoic acid

Gap 26 is a peptide mimetic of connexin, specifically representing residues 63-75 of connexin 43, and functions as a gap junction blocker.

(Arg)9 TFA salt

H-Leu-leu-OH

Glycyl-DL-phenylalanine

Nalpha-glycyl-L-asparagine