Chemicals & Small Molecules

(+)-JQ-1-PEG4-Amido-N-t-Boc possesses a Boc-protected amino (NH2) group, which is reactive with activated NHS esters or carboxylic acid in the presence of EDC or HATU, and (+)-JQ-1, which functions as a potent, specific, and reversible pan-BET (bromodomain and extra-terminal motif) family inhibitor. t-Boc-aminooxy can be deprotected under mild acidic conditions. (+)-JQ-1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. The PEG4 spacer bolsters hydrophilicity.

(+)-JQ-1-PEG4-Amine, TFA salt features an amino (NH2) group reactive with activated NHS esters or carboxylic acids in the presence of EDC or HATU. It includes (+)-JQ-1, a potent, specific, and reversible pan-BET family inhibitor useful for studying BET bromodomains in oncogenesis. The PEG4 linker adds water solubility to the compound.

Fluorescein-PEG4-DBCO is a xanthene dye containing a reactive DBCO group and a hydrophilic PEG spacer arm with excitation/emission maximum of 494/517 nm. DBCO reacts with azide-bearing compounds or biomolecules to form a stable triazole linkage without copper catalysts. It could be used as a quantum yield standard. Hydrophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fluorescein-PEG4-Mal is a xanthene dye containing a maleimide group, which selectively reacts with free thiol, sulfhydryl, or mercapto group via Michael addition to form a stable carbon sulfur bond. It could be used as a quantum yield standard. Hydrophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fluorescein-PEG4-Propargyl is a xanthene dye that reacts with terminal azide via a copper-catalyzed click reaction (CuAAC) to form a stable triazole linker. It is a popular labeling dye used in Click Chemistry reactions. It could be used as a quantum yield standard. Hydrophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fluorescein-PEG8-Propargyl is a xanthene dye that reacts with terminal azide via a copper-catalyzed click reaction (CuAAC) to form a stable triazole linker. It is a popular labeling dye used in Click Chemistry reactions. It could be used as a quantum yield standard. Hydrophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fluorescein-PEG8-DBCO is a xanthene dye containing a reactive DBCO group and a hydrophilic PEG spacer arm with excitation/emission maximum of 494/517 nm. DBCO reacts with azide-bearing compounds or biomolecules to form a stable triazole linkage without copper catalysts. It could be used as a quantum yield standard. Hydrophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fluorescein-PEG8-amine, TFA salt is a xanthene dye with excitation/emission maximum of 494/517 nm and an amine group. The amine group makes the compound more reactive toward carboxylic acids, NHS esters and other carbonyl groups. It could be used as a quantum yield standard. Hydrophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BDP FL-PEG8-Azide is a BDP FL linker containing an azide group. It can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures. BDP FL-PEG8-Azide is a bright and photostable thiol-reactive dye for protein labeling, peptide modification, and can replace fluorescein for microscopy. The hydrophilic PEG spacer arm increases water solubility, membrane permeability, and conjugation efficiency. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.