Chemicals & Small Molecules

AMCA-PEG8-Azide is a fluroescent reagent with an azide group for click chemistry conjugation with terminal alkynes via a copper-catalyzed click reaction or strained cyclooctynes via a copper-free click reaction. The hydrophilic PEG spacer arm increases water solubility, membrane permability, and conjugation efficiency. AMCA-PEG8-Azide is a popular blue fluorescent tagging molecule that has a maximal absorption of 345 nm and emission at 450 nm. This dye is used for protein and peptide labeing. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

1-(PEG-Amine)-2,3-(PEG4-Azide) is a branched PEG linker with a terminal amine that can be further derivatized for conjugation and two terminal azides that participate in click chemistry with linear alkynes, DBCO, and BCN.

Azide-PEG8-Val-Cit-PAB-MMAF serves as a linker-payload containing an azide click chemistry handle for click reactions with DBCO, BCN, and linear alkynes. MMAE is a synthetic antineoplastic agent which can be employed as a payload in the construction of ADCs (antibody-drug conjugates).The PEG chain enhances the water-solubility of the molecule.

Amine-PEG8-benzyl ester contains an amine, which can be further derivatized, and a benzyl ester, which can be used to protect carboxyl groups from reactions that can occur at amino groups and can be deprotected under catalytic hydrogenic conditions.

AMCA-PEG4-DBCO is a AMCA dye containing a reactive DBCO group and a hydrophilic PEG spacer arm with excitation/emission maximum of 345/450 nm. DBCO reacts with azide-bearing compounds or biomolecules to form a stable triazole linkage without copper catalysts. It could be used as a quantum yield standard. Hydrophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

TCO-PEG2-NHS ester serves as a heterobifunctional PEG linker comprised of a TCO click chemistry handle that readily reacts with tetrazine groups and NHS ester that directly and efficiently reacts with amine-bearing molecules. The PEG spacer imparts water solubility.

t-Boc-N-MMAF

Biotin-PEG11-NHCO-MMAF-N-t-Boc functions as a biotinylation reagent with the biotin moiety linked to an MMAF payload protected by a Boc group which can be removed under acidic conditions to reveal the free amine. The connecting PEG arm enhances the water-solubility of the compound.

Biotin-PEG11-NHCO-MMAF-N-t-Boc acts as a biotinylation reagent with the biotin moiety linked to an MMAF payload for antibody-drug conjugates (ADCs) via a PEG chain that improves the hydrophilicity of the molecule.