Chemicals & Small Molecules

M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in vitro and in vivo animal models. It is useful for research into nervous system diseases [1].

PIK5-12d is a PROTAC PIKfyve degrader with antitumor activity that induces massive cytoplasmic vacuolization and blocks autophagic flow. PIK5-12d inhibits the value-added of cancer cells and can be used in the study of prostate cancer.

MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are critical steps in cell necrosis. Additionally, MLKL-IN-6 restrains immune cell death, diminishes adhesion factor expression, exhibits low cytotoxicity, impedes hepatic stellate cell activation, decreases liver fibrosis marker levels, and exerts anti-fibrotic effects [1].

VU6004909 is a positive allosteric modulator of the mGlu5 receptor (pEC50: 7.59), exhibiting antipsychotic-like effects. It has the capability to reverse MK801-induced cortical hyperactivity and cognitive deficits [1] [2].

Compound 142 (also known as Compound 235) is a PTPN inhibitor with potential applications in cancer research [1].

Anticancer Agent 143 (Compound 369), a potent dual inhibitor targeting PTPN2 and PTP1B, exhibits IC50 values below 2.5 nM. It is employed in cancer research [1].

Nevadistinel (NYX-458; NYX-3054) is a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, indicated for mitigating cognitive deficits related to neurodegenerative conditions, including mild cognitive impairment, mild Alzheimer's disease, Parkinson's disease, and Lewy body disease [1].

Usnoflast functions as an NLRP3 modulator and also serves as a non-steroidal anti-inflammatory agent (NSAID) [1].

Bovine Type II Collagen (Collagen Type II,Bovine) is a homologous superhelical structure consisting of three identical α1(II) chains, and is a major component of animal cartilage. Type II collagen has a variety of biological activities, including maintaining cartilage tissue integrity, inducing immune tolerance, and stimulating chondrocyte growth and redifferentiation.