Activators & Inhibitors

(±)5(6)-EpETE methyl ester (Legacy Tebubio ref. 282T37224). (±)5(6)-EpETE methyl ester ((±)5,6-EEQ methyl ester) is biosynthesized from cytochrome P450.1.2 in rat and rabbit liver microsomes and is involved in Ca2 mobilization and hormone secretion in neuroendocrine cells.

(±)7(8)-DiHDPA (Legacy Tebubio ref. 282T37225). (±)7(8)-DiHDPA, a major metabolite of docosahexaenoic acid produced via oxidation by cytochrome P450 epoxygenases, inhibits aggregation and thromboxane synthesis in isolated platelets.

(±)7(8)-EpDTE (Legacy Tebubio ref. 282T37226). (±)7(8)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid (DPA), formed via cytochrome P450 (CYP) metabolism, and can be further metabolized to (±)7(8)-DiHDTE by epoxide hydrolase.

(±)8(9)-DiHET (Legacy Tebubio ref. 282T37227). Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.

(±)8(9)-EpETE (Legacy Tebubio ref. 282T37228). (±)8(9)-EpETE ((±)8,9-EEQ) is an epoxide of arachidonic acid biosynthesized by cytochrome P-450 (CYP450) epoxy synthase, which is specific for glomerular protection, dose-dependently prevents fspf-induced Palb, activation of Ca2+-activated K+ (BKCa) channels, and is used in the study of cardiovascular disease.

(±)8,9-DiHETE (Legacy Tebubio ref. 282T37229). (±)8,9-DiHETE is a major metabolite of the 20:5 ω-3 fatty acid eicosapentaenoic acid .[1] It is produced in rat liver microsomes, but not renal microsomes, by the generation of the unstable intermediate 8,9-epoxy eicosatetraenoic acid from EPA by cytochrome P450 monooxygenases. Dietary EPA supplementation in humans results in substantial urinary excretion of vicinal diols, including 8,9, 11,12, and 14,15 forms.[2]

Dioxopromethazine hydrochloride (Legacy Tebubio ref. 282T3723). Dioxopromethazine is a target-based classification of drug and available in a number of countries worldwide.

(+)-5-trans Cloprostenol (Legacy Tebubio ref. 282T37230). Cloprostenol is a synthetic derivative of prostaglandin F2α that is used in veterinary medicine as a luteolytic agent for the induction of estrus and in the treatment of reproductive disorders in cattle, swine, and horses. (+)-5-trans Cloprostenol is a minor impurity produced in the synthesis of (+)-cloprostenol. The (+)-5-trans isomer is 20-fold less active than the 5-cis form in terminating pregnancy in the hamster.

(+)-Cloprostenol methyl ester (Legacy Tebubio ref. 282T37231). (+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. It is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2α. Cloprostenol is also used in veterinary medicine as a luteolytic agent for the induction of estrus and the treatment of reproductive disorders in cattle, swine, and horses. (+)-Cloprostenol methyl ester is a more lipid soluble form of cloprostenol, which may be more amenable for certain formulations.