Activators & Inhibitors

MXS (Legacy Tebubio ref. 282T37357). MXS is a mitochondria-targeted fluorescent probe for hypochlorous acid (HOCl).1It selectively fluoresces in the presence of OCl-over O2, H2O2, NO, NO2-, NO3-, O2-, ONOO-, and OH when used at a concentration of 10 μM. MXS has been used to monitor real-time mitochondrial HOCl levels in living cells. It displays excitation/emission maxima of 530/654 nm, respectively.

Myristelaidic Acid (Legacy Tebubio ref. 282T37358). Myristelaidic Acid is a natural product for research related to life sciences. The catalog number is T37358 and the CAS number is 50286-30-1.

Myristoyl-L-carnitine chloride (Legacy Tebubio ref. 282T37359). Myristoyl-L-carnitine chloride (L-Myristoylcarnitine chloride) is one of the body's metabolites implicated in inherited metabolic disorders.Tetradecanoylcarnitine is a potential marker for the study of diabetes mellitus and autoimmune hepatitis.

Olivetol (Legacy Tebubio ref. 282T3736). Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of tetrahydrocannabinol. Olivetol has an antioxidant effect.

6-O-desmethyl Donepezil (Legacy Tebubio ref. 282T37360). 6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil . It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6. It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 μM in HEK293 cells expressing hERG).

6β-hydroxy Dexamethasone (Legacy Tebubio ref. 282T37361). 6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans., The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.

7α-Thiomethylspironolactone (Legacy Tebubio ref. 282T37362). 7α-Thiomethylspironolactone is a major metabolite of the synthetic steroid spironolactone.1,2

7-hydroxy Coumarin Glucuronide (sodium salt) (Legacy Tebubio ref. 282T37364). 7-hydroxy Coumarin glucuronide is a 7-hydroxy coumarin phase II metabolite that can be used as a standard for the analysis of 7-hydroxy coumarin metabolism.

7-hydroxy Coumarin sulfate (potassium salt) (Legacy Tebubio ref. 282T37365). 7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS.