Activators & Inhibitors

13(S)-HpOTrE(γ) (Legacy Tebubio ref. 282T37395). 13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid. Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE. At concentrations greater than 100 μM, 13(S)-HpOTrE(γ) inhibits the activity of soybean LO-1.

13-epi-12-oxo Phytodienoic Acid (Legacy Tebubio ref. 282T37396). 13-epi-12-oxo Phytodienoic acid (13-epi-12-oxo PDA) is a lipoxygenase metabolite of α-linolenic acid in the leaves of green plants such as corn. ω-3 and ω-6 polyunsaturated fatty acids in plants are substrates for plant lipoxygenases. 12-oxo PDA is one of the best studied end metabolites of this enzymatic pathway. While the initial enzymatic product and major isomer of 12-oxo PDA contains side chains in the cis position, both being β to the ring, the upper side chain attached at C-13, can and frequently does, isomerize when 12-oxo PDA is extracted, isolated, or stored. 13-epi-12-oxo PDA is the product of this isomerization.

15(S)-HEDE (Legacy Tebubio ref. 282T37397). 15(S)-HEDE is produced from 11Z,14Z-eicosadienoic acid by 15-LO. 15(S)-HEDE is an inhibitor of RBL-1 cell 5-LO with an IC50 value of 26 μM.

15(S)-HETE methyl ester (Legacy Tebubio ref. 282T37399). 15(S)-HETE methyl ester is a synthetic derivative of 15(S)-HETE , a major arachidonic acid metabolite from the 15-lipoxygenase pathway. Methyl esters of lipids are commonly used in formulations of nutritional supplements.

Isovanillin (Legacy Tebubio ref. 282T3740). Isovanillin (5-Formylguaiacol) is a reversible inhibitor of aldehyde oxidase. It is largely used as pharmaceutical intermediates and also applied in food and beverage industry, synthetic fragrances, chemical.

15(S)-HETrE (Legacy Tebubio ref. 282T37400). 15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid. It inhibits 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15(S)-HETrE also inhibits 5-LO, but is approximately 1/20 as potent as 15(S)-HpETE.

15(S)-HpEDE (Legacy Tebubio ref. 282T37401). 15(S)-HpEDE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosadienoic acid. Although the biological activities of 15(S)-HpEDE have not been well characterized, it is expected to behave similarly to 15(S)-HpETE.

15(S)-HpEPE (Legacy Tebubio ref. 282T37402). 15(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosapentaenoic acid. Although the biological activities of 15(S)-HpEPE have not been well characterized, it is expected to behave similarly to 15(S)-HpETE.

O-desmethyl Brinzolamide (hydrochloride) (Legacy Tebubio ref. 282T37403). O-desmethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1,2It inhibits CAII and CAIV (IC50s = 0.136 and 165 nM, respectively).1