Activators & Inhibitors

UZH1a (Legacy Tebubio ref. 282T37448). UZH1a is a potent and selective inhibitor of METTL3, with an IC50 of 280 nM. It serves as a tool for the epitranscriptomic modulation of cellular processes, exhibits antitumor activity, and functions as a chemical probe for the study of METTL3[1].

SR 12460 (Legacy Tebubio ref. 282T37449). SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1It inhibits TNF-α-induced NF-κB activation in a reporter assay when used at concentrations ranging from 25 to 150 μM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in themdxmouse model of Duchenne muscular dystrophy.

3,4-Dimethoxyphenol (Legacy Tebubio ref. 282T3745). 3,4-Dimethoxyphenol (4-Hydroxyveratrole) is an active biochemical.

SSK1 (Legacy Tebubio ref. 282T37450). SSK1 is a compound that selectively kills senescent cells and is a precursor for β-galactosidase, which can reduce the inflammatory response of the body. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, and promote mitochondrial DNA damage in senescent cells.

Stachybotrysin B (Legacy Tebubio ref. 282T37451). Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2

Stephacidin B (Legacy Tebubio ref. 282T37452). Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatocellular carcinoma cells when used at a concentration of 4 μM.3

Butyryl-L-carnitine (chloride) (Legacy Tebubio ref. 282T37453). Butyryl-L-carnitine is a butyrate ester of carnitine. It is an inhibitor of intestinal transporters, blocking carnitine uptake by the carnitine transporter and glycine transport by the amino acid transporter in human retinal pigment epithelial (HRPE) cells (IC50s = 1.5 μM and 4.6 mM, respectively).

C16 dihydro Ceramide (d18:0/16:0) (Legacy Tebubio ref. 282T37454). C16 dihydro Ceramide (d18:0/16:0) (Cer(d18:0/16:0)) is a precursor for the synthesis of ceramides, induces autophagy in the perinuclear region, and can be used to study cell membrane stability and neurological diseases.

C18 D-threo Ceramide (d18:1/18:0) (Legacy Tebubio ref. 282T37455). C18 D-threoCeramide (d18:1/18:0) is a synthetic ceramide and stereoisomer of C18 ceramide .1It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50value of 16.6 μM.2