Activators & Inhibitors

11-trans Leukotriene D4 (Legacy Tebubio ref. 282T37493). 11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25% of the potency for contraction of guinea pig ileum, trachea, and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.

11-trans Leukotriene E4 (Legacy Tebubio ref. 282T37494). Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.

Angiotensin (1-7) acetate (Legacy Tebubio ref. 282T37495). Angiotensin (1-7) acetate (Ang-(1-7) acetate) is an amino acid sequence present in angiotensin, which has antifibrotic and cardioprotective effects and inhibits the activity of purified canine angiotensin converting enzyme (ACE). Angiotensin (1-7) acetate inhibits the growth of tumor cells and reduces local inflammation and angiogenesis in several types of cancer, blocks angiotensin II-induced smooth muscle cell proliferation and hypertrophy, and can be used to study atherosclerosis and novel coronavirus infection.

Alamandine TFA (Legacy Tebubio ref. 282T37496L). Alamandine TFA , a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine TFA targets to protect the kidney and heart through anti-hypertensive actions[1][2].

Antimycin A2 (Legacy Tebubio ref. 282T37497). Antimycin A2 is one of the active ingredients of the crystalline antibiotic complex.

Antimycin A4 (Legacy Tebubio ref. 282T37498). Antimycin A4 is an active component of the antimycin A antibiotic complex that is more polar than antimycin A1 , antimycin A2 , and antimycin A3 . Antimycin A4 inhibits ATP-citrate lyase with a Ki value of 64.8 μM. The antimycin A complex is a mixture of antimycins A1, A2, A3, and A4 that demonstrates antifungal, insecticidal, nematocidal, and piscicidal properties. It blocks mitochondrial respiration and can deplete cellular levels of ATP via inhibition of complex III of the mitochondrial electron transport chain (ETC). Antimycin A prevents the transfer of electrons between the b-cytochromes and ubiquinone at the Q(inner) site of complex III. This results in the stabilization of the ubisemiquinone radical at the Q(outer) site of complex III, leading to increased production of superoxide. Antimycin A is widely used in research to shunt electron flow through the ETC to study the chemical details of oxygen respiration. Additionally, antimycin

Estriol 3-glucuronide (Legacy Tebubio ref. 282T37499). Estriol-3-glucuronide, a natural compound found in urine, is also present in amniotic fluid during normal pregnancy [1][2].

4-Hydroxyacetophenone (Legacy Tebubio ref. 282T3750). 4-Hydroxyacetophenone (4-Acetylphenol) is a potent xanthine oxidase inhibitor.

Etherolenic Acid (Legacy Tebubio ref. 282T37500). Etherolenic acid is a divinyl ether oxylipin.1,2It is a metabolite of linolenic acid that is formed in plantsvia13-lipoxygenase-mediated formation of 13(S)-HpOTrE followed by conversion to the divinyl ether by divinyl ether synthase.