Activators & Inhibitors

Leukotriene C4 methyl ester (Legacy Tebubio ref. 282T37620). Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM. LTC4 methyl ester is a more lipid soluble form of LTC4. The biological activity of LTC4 methyl ester has not been reported.

Ezeprogind disulfate (Legacy Tebubio ref. 282T37621). Ezeprogind disulfate is a neurotrophic inducer. Ezeprogind disulfate targets all causes of neurodegeneration including Abeta protein or tau protein. Ezeprogind disulfate can be used for the research of neurological disorders, including progressive supranu

F13714 fumarate (Legacy Tebubio ref. 282T37622). F13714 fumarate is a selective 5-HT1A receptor-biased agonist with antidepressant-like properties after a single dose in a mouse model of chronic mild stress.

1,2-Dierucoyl-sn-glycero-3-PC (Legacy Tebubio ref. 282T37623). 1,2-Dierucoyl-sn-glycero-3-PC is a phospholipid with erucic acid at the sn-1 and sn-2 positions, employed in studies of lipid membranes and assessing the impact of long-chain phospholipids on the secondary structure of human islet amyloid polypeptide (hIAPP).

Latanoprost amide (Legacy Tebubio ref. 282T37625). Latanoprost amide is a derivative of latanoprost.

Latanoprost dimethyl amide (Legacy Tebubio ref. 282T37626). Latanoprost dimethyl amide is a derivative of latanoprost and an isomer of latanoprost ethyl amide.

Latanoprost ethyl amide (Legacy Tebubio ref. 282T37627). Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters exhibit ocular hypotensive activity, and prostaglandin N-ethyl amides have recently been introduced as alternative ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to free acids in vivo, studies in our laboratories show that bovine and human corneal tissue can convert the N-ethyl amides of various prostaglandins to free acids at a rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt is expected to exhibit the typical intraocular effects of latanoprost free acid, but with much slower hydrolysis pharmacokinetics characteristic of prostaglandin N-amides.

Ibuprofen impurity 1 (Legacy Tebubio ref. 282T37628). Ibuprofen impurity 1 is a known impurity of Ibuprofen, an anti-inflammatory inhibitor that targets COX-1 and COX-2 with IC50 values of 13 μM and 370 μM, respectively[1].

Fumaric acid (Legacy Tebubio ref. 282T3763). Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.