Activators & Inhibitors

trans-2-Hexadecenoyl-L-carnitine (Legacy Tebubio ref. 282T37640). Trans-2-Hexadecenoyl-L-carnitine is an endogenous metabolite found in urine[1].

trans-2-Octenoyl-L-carnitine (Legacy Tebubio ref. 282T37641). trans-2-Octenoyl-L-carnitine, a synthetic carnitine, has been used as a standard for detecting carnitines in human urine.

Pravastatin lactone (Legacy Tebubio ref. 282T37642). Pravastatin lactone is a metabolite of pravastatin , a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor that is a ring-hydroxylated metabolite of mevastatin . Pravastatin lactone is formed when pravastatin undergoes acid-catalyzed non-enzymatic lactonization in the stomach following oral administration.

Propiverine N-oxide (hydrochloride) (Legacy Tebubio ref. 282T37643). Propiverine N-oxide (hydrochloride) is the major metabolite of propiverine in human plasma or urine.

Dasatinib metabolite M6 (Legacy Tebubio ref. 282T37645). Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative derivative of Dasatinib, a potent and orally active inhibitor of both Bcr-Abl and Src family tyrosine kinases[1].

HB007 (Legacy Tebubio ref. 282T37646). HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for investigating brain, breast, colon, and lung cancers[1][2].

5α-dihydro Levonorgestrel (Legacy Tebubio ref. 282T37647). 5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel . It lacks in vitro and in vivo estrogenic activity, but induces copulatory behavior in male rats when administered at a dose of 1 mg per animal per day.

5(R)-HETE (Legacy Tebubio ref. 282T37648). 5(R)-HETE is a rare lipoxygenase product of arachidonic acid. Nearly all plant and animal 5-LOs produce 5(S)-HETE, but the presence of a 5(R)-LO and the synthesis of 5(R)-HpETE and 5(R)-HETE have been confirmed in oocytes of the bivalve mollusk, S. solidissima. 5(R)-HETE is more potent than the (S)-enantiomer as a chemotactic agent for human neutrophils.

5(S),12(S)-DiHETE (Legacy Tebubio ref. 282T37649). 5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid . It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA. 5(S),12(S)-DiHETE can be produced by successive oxygenation of AA by 5-lipoxygenase (5-LO) in platelets and 12-LO in leukocytes. It can also be synthesized from 12(S)-HETE by 5-LO, in the presence of 5-LO activating protein (FLAP), activated with calcium ionophore. 5(S),12(S)-DiHETE is an epimer of leukotriene B4 that is weakly chemotactic for PMNL.