Activators & Inhibitors

Org 24598 lithium salt (Legacy Tebubio ref. 282T37700). Org 24598 lithium salt is a GlyT-1 inhibitor of glycine transporter 1. Org 24598 lithium salt inhibits the specific binding of [3H]CHIBA-3007 to rat meninges (Ki=16.9 nM).

pep4c (Legacy Tebubio ref. 282T37701). pep4c can be used for related research in the field of life sciences. Its product number is T37701 and CAS number is 243843-43-8.

Pancuronium (bromide hydrate) (Legacy Tebubio ref. 282T37702). Pancuronium is an aminosteroid antagonist of muscle-type nicotinic acetylcholine receptors (nAChRs) with an IC50value of 14.8 nM using patch clamp electrophysiology in BOSC23 cells expressing mouse nAChRs.1It acts as a non-depolarizing neuromuscular blocking agent.2Pancuronium enhances anesthesia induced by isoflurane , reducing immobilization with an ED50value of 1.62 μg/kg.3

Olanzapine Lactam Impurity (Legacy Tebubio ref. 282T37704). Olanzapine lactam impurity is a potential impurity found in commercial preparations of olanzapine.1It is a degradation product formed by exposure to thermal or oxidative stress.

1,2,4-Trihydroxybenzene (Legacy Tebubio ref. 282T37705). 1,2,4-Trihydroxybenzene (Benzene-1,2,4-triol) is a by-product of coffee bean roasting and is found in mouse, arabica coffee.1,2,4-Trihydroxybenzene is a benzotriol that increases Ca2+ concentration in rat thymic lymphocytes.

1,3-Dipalmitoyl-2-Octanoyl-rac-glycerol (Legacy Tebubio ref. 282T37706). 1,3-Dipalmitoyl-2-octanoyl-rac-glycerol is a triacylglycerol that contains palmitic acid at the sn-1 and sn-3 positions and octanoic acid at the sn-2 position.

14-Anhydrodigitoxigenin (Legacy Tebubio ref. 282T37707). 14-Anhydrodigitoxigenin is a cardenolide and a derivative of digitoxin.1 It reduces the activity of guinea pig heart Na+/K+-ATPase by 15% when used at a concentration of 10 μM.2

17(R)-HETE (Legacy Tebubio ref. 282T37708). Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. 17(R)-HETE is an inactive isomer of 17-HETE, whereas the (S) enantiomer can inhibit proximal tubule ATPase activity at a concentration of 2 μM.

2,2,2-Trichloroethanol (Legacy Tebubio ref. 282T37709). 2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4). It activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery [1]. [1]. Nikhil K Parelkar, et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332(3):803-10.