Activators & Inhibitors

GLP-1(32-36)amide acetate (Legacy Tebubio ref. 282T37891L). GLP-1(32-36)amide acetate is a pentapeptide and derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide acetate could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.

GLP-1(7-36), amide TFA (Legacy Tebubio ref. 282T37892). GLP-1(7-36), amide TFA is a prominent intestinal hormone that stimulates glucose-induced insulin secretion from β cells[1].

3-MPPI (Legacy Tebubio ref. 282T37893). 3-MPPI was a high-affinity nonselective α1-antagonist.

4-Nitrophenyl Phenylphosphonate (Legacy Tebubio ref. 282T37895). 4-Nitrophenyl phenylphosphonate is a substrate for 5'-nucleotide phosphodiesterases. It is a more preferable substrate to 5'-nucleotide phosphodiesterases than naturally occurring nucleotides or bis(4-nitrophenyl) phosphate because of its stability, ease of synthesis, and higher rate of hydrolysis under saturating conditions.

AZ 1729 (Legacy Tebubio ref. 282T37896). FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assays, displays positive allosteric modulation of FFA-induced Gi signaling and negative allosteric modulation of FFA-induced Gq/G11 signaling. Inhibits lipolytic effect of isoproterenol (pEC50 = 5.03) and induces migration of human neutrophils in vitro.

AM-6538 (Legacy Tebubio ref. 282T37897). AM6538, a long-acting, high-affinity, and pseudo-irreversible cannabinoid antagonist structurally analogous to rimonabant, is a valuable tool for assessing the apparent efficacy of cannabinoid partial and full agonists. It also holds potential for future investigations requiring temporary reductions in cannabinoid receptor availability[1].

UDP-α-D-Glucose (sodium salt hydrate) (Legacy Tebubio ref. 282T37898). UDP-α-D-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to bind the P2Y14receptor (EC50= 0.35 μM), an atypical P2Y receptor involved in the activation of dendritic cells and glial cells.1It can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 μM.2

UDP-β-D-Glucose (sodium salt) (Legacy Tebubio ref. 282T37899). UDP-β-D-Glucose is the stereoisomer of UDP-α-D-glucose (sodium salt) . The activities of the UDP-β-D-glucose isomer are not known.

Hederacoside D (Legacy Tebubio ref. 282T3790). Hederacoside D is a bioactive saponins from Hedera helix.