Activators & Inhibitors

Tenofovir diphosphate (Legacy Tebubio ref. 282T37909). Tenofovir diphosphate (TFV-DP) is a competitive inhibitor of DNA polymerases, specifically targeting dATP, and functions as a substrate for the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1)[1].

Atractyloside A (Legacy Tebubio ref. 282T3791). Atractyloside is a glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEPIS. Toxicity is due to inhibition of adenine nucleotide translocase.

Tenofovir diphosphate triethylamine (Legacy Tebubio ref. 282T37910). Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitive inhibitor of DNA polymerases for dATP and acts as a substrate for HIV type 1 reverse transcriptase (HIV-1 RT)[1].

cis-Resveratrol (Legacy Tebubio ref. 282T37911). cis-Resveratrol ((Z)-Resveratrol) has antiviral activity, inhibits enteroviruses, increases TyrRS, promotes histone serine-ADP ribosylation-dependent DNA repair, and provides neuroprotection in a TyrRS-dependent manner.

Pipacycline (Legacy Tebubio ref. 282T37914). Pipacycline is a tetracycline antibiotic derivative. It inhibits the formation of penicillinase, the enzyme that inactivates penicillin in bacteria. It decreases oxygen uptake and inhibits growth of penicillin-resistant penicillinase-producing S. aureus.

Monodes(N-carboxymethyl)valine Daclatasvir (Legacy Tebubio ref. 282T37915). Monodes(N-carboxymethyl)valine Daclatasvir, also known as Daclatasvir Impurity A, is the principal degradation product of Daclatasvir.Daclatasvir is a potent inhibitor of the HCV NS5A protein[1].

5,6-epoxy-13-cis Retinoic Acid (Legacy Tebubio ref. 282T37916). 5,6-epoxy-13-cis Retinoic Acid is a metabolite of 13-cis retinoic acid.

5-hydroxy Diclofenac (Legacy Tebubio ref. 282T37917). 5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4. Diclofenac is a non-selective COX inhibitor. It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 μM, respectively. Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.

Prostaglandin E2 isopropyl ester (Legacy Tebubio ref. 282T37918). Prostaglandin E2 (PGE2) isopropyl ester is a more lipophilic form of the free acid, PGE2. PG esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid by endogenous esterases upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of PGs show greatly diminished receptor activity in vitro compared to the parent free acids.