Activators & Inhibitors

Sphinganine-1-phosphate (d17:0) (Legacy Tebubio ref. 282T37952). Sphinganine-1-phosphate (d17:0) is a sphingolipid analog of sphinganine-1-phosphate (d18:0) and sphingosine-1-phosphate (d18:1) that has a 17-carbon base. Sphinganine-1-phosphate (d17:0) levels are lower in surgical and cadaver trabecular meshwork samples isolated from patients with primary open angle glaucoma compared with control samples.

Sphingomyelins (buttermilk) (Legacy Tebubio ref. 282T37953). Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.1SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling.2This product is a mixture of SMs, with variable fatty acyl chain lengths, isolated from buttermilk.

Sphingosine (d20:1) (Legacy Tebubio ref. 282T37954). Sphingosines are long-chain base precursors of cellular sphingolipids used directly in the synthesis of ceramide, which in combination with sialic acid forms ganglioside. Sphingosine can exist in four stereoisomers, however only sphingosine occurs naturally. Compared to other sphingolipids throughout the body, which are predominantly composed of C-18 sphingosine, only central nervous system (CNS) gangliosides contain significant amounts of sphingosine. The concentration of sphingosine within mammalian brain gangliosides apparently increases with developmental maturation. Furthermore, the ratio of C-18 to C-20 sphingosine in the brain is thought to be related to some nervous system degeneration processes.

Sphingosine-1-phosphate (d16:1) (Legacy Tebubio ref. 282T37955). C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO cells. C16 S1P was increased in postmortem primary open angle glaucoma trabecular meshwork samples.

Tafluprost ethyl amide (Legacy Tebubio ref. 282T37956). Tafluprost ethyl amide, a prostaglandin derivative, reduces intraocular pressure (IOP) and affects eyelash growth, making it suitable for use in anti-glaucoma eye drops and cosmetics.

Setosusin (Legacy Tebubio ref. 282T37957). Setosusin is a meroterpenoid fungal metabolite originally isolated from C. setosus. It reduces neurotoxicity induced by amyloid-β (Aβ) aggregates in PC12 cells (EC50 = 112.6 μM).

Acetyl Coenzyme A trisodium (Legacy Tebubio ref. 282T37958). Acetyl Coenzyme A trisodium (Acetyl-CoA trisodium) is an important compound in glucose metabolism and lipid metabolism and is involved in the tricarboxylic acid cycle.

GS-704277 (Legacy Tebubio ref. 282T37959). GS-704277, an alanine metabolite derived from Remdesivir, a nucleoside analogue acknowledged for its potent antiviral efficacy, demonstrates remarkable effectiveness in vitro for the management of SARS-CoV-2 (COVID-19) infection[1][2].

Betulinaldehyde (Legacy Tebubio ref. 282T3796). Betulinaldehyde (Betunal) has the inhibition of Saccharomyces sp and alpha-glucosidase. Betulinaldehyde induces apoptosis in mouse B16 2F2 cells. Betulinaldehyde has anti-proliferative activity against mouse +SA mammary epithelial cells.