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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 18112 )

      • Paraxanthine

        Ref: T4973
        Sizes: 25 mg, 100 mg, 50 mg, 200 mg
        From: €65.00

        Paraxanthine (Legacy Tebubio ref. 282T4973). Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is structurally similar to caffeine and possibly mediates the physiological effects of caffeine. Also Paraxanthine acts as a competitive phosphodiesterase inhibitor, which increases intracellular cAMP, activates PKA, inhibits TNF-α and leukotriene synthesis. In addition, Paraxanthine acts as a Na+/K+ ATPase enzymatic effector.

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      • SM 16

        Ref: T4975
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €44.00

        SM 16 (Legacy Tebubio ref. 282T4975). SM 16 is an ALK5/ALK4 kinase inhibitor with Ki values of 10 nM and 1.5 nM, respectively.

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      • Umbralisib

        Ref: T4976
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €47.00

        Umbralisib (Legacy Tebubio ref. 282T4976). Umbralisib (TGR 1202) is a PI3Kδ inhibitor.

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      • Sofalcone

        Ref: T4977
        Sizes: 1 g, 100 mg, 500 mg, 200 mg
        From: €55.00

        Sofalcone (Legacy Tebubio ref. 282T4977). Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.

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      • Sarpogrelate hydrochloride

        Ref: T4978
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €47.00

        Sarpogrelate hydrochloride (Legacy Tebubio ref. 282T4978). Sarpogrelate hydrochloride (MCI-9042) , a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recepter Sarpogrelate is a drug which acts as an antagonist at the 5HT2A and 5-HT2B receptors. Sarpogrelate hydrochloride was shown to have the same affinity as ritanserin for 5-HT2A receptors, with a Ki value of 8.39 nM. Sarpogrelate hydrochloride lacked prominent 5-HT1-like, 5-HT3, beta, H1, H2 and M3 antagonist activity and weakly blocked alpha 1-adrenoceptors (pKB = 6.30). (S)-M-1 showed weak affinity for 5-HT1-like receptors (pKB = 6.30), alpha 1- (pKB = 6.80) and beta- (pKB = 6.54) adrenoceptors, while (R)-M-1 was a weak antagonist at histamine H1 receptors (pKB = 6.49). After 12 weeks of sarpogrelate administration, FBF and LBF responses during RH showed significant increases from 13.2 +/- 1.7 to 18.1 +/- 2.2 mL/min per 100 mL tissue (P < 0.01) and from 8.2 +/- 0.9 t

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      • Procyclidine hydrochloride

        Ref: T4979
        Sizes: 25 mg, 1 mL * 10 mM (in DMSO)
        From: €33.00

        Procyclidine hydrochloride (Legacy Tebubio ref. 282T4979). Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) is a potent anticholinergic agent and also have NMDA antagonist properties.

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      • Betrixaban maleate

        Ref: T4980
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 2 mg
        From: €35.00

        Betrixaban maleate (Legacy Tebubio ref. 282T4980). Betrixaban maleate is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa.

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      • Anisotropine Methylbromide

        Ref: T4981
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg
        From: €35.00

        Anisotropine Methylbromide (Legacy Tebubio ref. 282T4981). Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.

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      • Benznidazol

        Ref: T4982
        Sizes: 25 mg, 100 mg, 50 mg, 1 mL * 10 mM (in DMSO)
        From: €36.00

        Benznidazol (Legacy Tebubio ref. 282T4982). Benznidazol (Benznidazole)e has an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis.

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