Activators & Inhibitors

Leukotriene F4 (Legacy Tebubio ref. 282T38129). LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle. [1] The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4. [1] [2]

20(R)-Ginsenoside Rh2 (Legacy Tebubio ref. 282T3813). 20(R)-Ginsenoside Rh2 (Ginsenoside Rh2) is a minor stereoisomer of ginsenoside Rh2, possesses matrix metalloproteinase inhibitory.

(E)-10-Hydroxynortriptyline (Legacy Tebubio ref. 282T38131). (E)-10-Hydroxynortriptyline (E-10-OH-NT) is an active metabolite of Nortriptyline with anxiolytic activity and affinity for muscarinic acetylcholine receptors, which can be used in the study of neurological disorders.

(S)-Higenamine hydrobromide (Legacy Tebubio ref. 282T38132). (S)-Higenamine hydrobromide, an S-enantiomer of Higenamine, serves as the preliminary compound in benzylisoquinoline alkaloid biosynthesis. It is formed through the condensation of dopamine and 4-hydroxyphenylacetaldehyde (4-HPAA) via norcoclaurine synthase (NCS)[1].

(S)-O-Desmethyl Venlafaxine N-Oxide (Legacy Tebubio ref. 282T38134). (S)-O-Desmethyl Venlafaxine N-Oxide, an N-oxide derivative of (S)-O-Desmethyl Venlafaxine, is an active metabolite of the serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant Venlafaxine[1][2].

3,4-Dehydro Cilostazol (Legacy Tebubio ref. 282T38135). 3,4-Dehydro Cilostazol (OPC-13015), an active metabolite of Cilostazol, is used for pharmacokinetic studies[1].

3,5-Dihydroxyacetophenone (Legacy Tebubio ref. 282T38136). 3,5-Dihydroxyacetophenone [3,5-DHAP] is a naturally occurring metabolite.

3,5-Dimethylbenzaldehyde (Legacy Tebubio ref. 282T38137). 3,5-Dimethylbenzaldehyde has broad-spectrum antimicrobial activity, inhibiting Bacillus subtilis, Pseudomonas albicans, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae.

ACEA (Legacy Tebubio ref. 282T38138). Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide , in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.