Activators & Inhibitors

C16 3'-sulfo Galactosylceramide (d18:1/16:0) (Legacy Tebubio ref. 282T38179). C16 3'-sulfo Galactosylceramide (d18:1/16:0) is a sulfated glycolipid.C16 3'-sulfo Galactosylceramide (d18:1/16:0) is a relatively abundant sulfide found in porcine brain and plasma that decreases throughout development in mice.C16 3'-sulfo Galactosylceramide is a relatively abundant sulfide found in porcine brain and plasma that decreases throughout development in mice.C16 3'-sulfo Galactosylceramide is a relatively abundant sulfide found in porcine brain and plasma that decreases throughout development in mice. C16 3'-sulfo Galactosylceramide (d18:1/16:0) inhibits retinal ganglion cell growth in vitro.C16 3'-sulfo Galactosylceramide (d18:1/16:0) has been used as an internal standard for quantifying C16 3'-sulfo Galactosylceramide (d18:1/16:0) in rat cerebellum and white matter isolated from patients with multiple sclerosis. reference for sulphides.

Fraxinol (Legacy Tebubio ref. 282T3818). Fraxinol is a predicted metabolite generated by BioTransformer1 that is produced by the metabolism of 5, 7-dimethoxy-2h-chromen-2-one. It is generated by cyp1a2, cyp2a6, cyp2b6, cyp2c9, cyp2c19, and cyp2e1 enzymes via an aromatic-hydroxylation-of-fused-benzene-ring-pattern1 reaction.

C16 Phytoceramide (t18:0/16:0) (Legacy Tebubio ref. 282T38180). C16 Phytoceramide (t18:0/16:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C16 Phytoceramide (t18:0/16:0) is composed of a phytosphingosine backbone amine-linked to a C16 fatty acid chain. The levels of C16 phytoceramide (t18:0/16:0) increase following heat stress in S. cerevisiae. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous penetration and psoriasis in vitro.

C17 Lactosylceramide (d18:1/17:0) (Legacy Tebubio ref. 282T38181). C17 Lactosylceramide is a naturally occurring sphingolipid that has been found in human brain metastases of lung adenocarcinomas but not in healthy brain tissue.

C17 Sphingomyelin (d18:1/17:0) (Legacy Tebubio ref. 282T38182). C17 Sphingomyelin, a synthetic derivative of sphingomyelin, is used as an internal standard for the quantification of sphingomyelin.

C18 3'-sulfo Galactosylceramide (d18:1/18:0) (Legacy Tebubio ref. 282T38183). C18 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. Levels of short-chain sulfatides, including C18 3'-sulfo galactosylceramide, decrease with age in mice and humans. It is increased in brain from mice with an arylsulfatase A deficiency (ASA-KO), particularly in lipid raft fractions. Plasma levels of C18 3'-sulfo galactosylceramide positively correlate with disability progression in patients with relapsing-remitting multiple sclerosis using the Expanded Disability Status Scale. It is also increased in plasma from patients with metachromatic leukodystrophy (MLD).

C18:1 3'-sulfo Galactosylceramide (d18:1/18:1(9Z)) (Legacy Tebubio ref. 282T38184). C18:1 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It has been found in mouse brain. It has been used as a standard for the quantification of C18:1 3'-sulfo galactosylceramide in dried blood spots from patients with metachromatic leukodystrophy (MLD) by UPLC-MS.

C2 3'-sulfo Galactosylceramide (d18:1/2:0) (Legacy Tebubio ref. 282T38185). C2 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It has been used as an internal standard in the quantification of lysosulfatides in mouse brain tissue and plasma.

6-Amino-8-trifluoromethylphenanthridine (Legacy Tebubio ref. 282T38186). 6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine. It inhibits the protein folding activity of the ribosome (PFAR) at a concentration of 150 μM and directly competes with protein substrates for the ribosomal active site.