Activators & Inhibitors

6-Aminophenanthridine (Legacy Tebubio ref. 282T38187). 6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz . 6-Aminophenanthridine (300 μM) inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate. It prevents progressive wing position defects in a Drosophila model of oculopharyngeal muscular dystrophy (OPMD) when larvae are raised on medium containing doses ranging from 300 to 400 μM and in adults following dietary administration of 1-3 mM doses. 6-Aminophenanthridine also reduces muscle degeneration and decreases the number of nuclear inclusions in thoracic muscle in a Drosophila model of OPMD.

7-Hydroxy-PIPAT maleate (Legacy Tebubio ref. 282T38188). 7-Hydroxy-PIPAT maleate is a D3R agonist.

2-hydroxy Lignoceric Acid (Legacy Tebubio ref. 282T38189). 2-hydroxy Lignoceric acid is an α-hydroxy very long chain fatty acid that is normally present in the mammalian nervous system. In the brain, 2-hydroxy lignoceric acid is derived from lignoceric acid and further converted to ceramides and cerebrosides during the process of nerve sheath myelination. 2-hydroxy Lignoceric acid is produced by the α-oxidation of lignoceric acid in the peroxisome and defects in this pathway are associated with disorders such as Zellweger syndrome.

Ursolic acid acetate (Legacy Tebubio ref. 282T3819). Ursolic acid acetate (Acetylursolic acid) has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities. Acetylursolic acid has inhibition against both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes.

Tyr-α-CGRP (rat) (trifluoroacetate salt) (Legacy Tebubio ref. 282T38190). Tyr-α-CGRP (rat) is an N-terminally tyrosinated analog of the neuropeptide α-CGRP that induces a fall in resting tension of isolated opossum internal anal sphincter (IAS) with an EC50 value of 178 nM.

Unguisin B (Legacy Tebubio ref. 282T38191). Unguisin B is a cyclic heptapeptide originally isolated from the marine fungus E. unguis whose structure is comprised of amino acids and GABA.

Unifiram (Legacy Tebubio ref. 282T38192). Unifiram is a cognition-enhancer. Unifiram induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the rat hippocampal CA1 region (EC50= 27 nM) and increases acetylcholine (ACh) release in the rat cerebral cortex.

β-Endorphin (1-27) (human) (trifluoroacetate salt) (Legacy Tebubio ref. 282T38193). β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors). It binds to rat and mouse brain membrane preparations (IC50s = 1.1 and 5.7 nM, respectively) and induces chemotaxis of human monocytes in vitro when used at a concentration of 1 nM. Intracerebroventricular administration of β-endorphin (1-27) increases the latency to tail withdrawal in response to thermal stimulation in mice with a median antinociceptive dose (AD50) of 1,500 pmol per animal. It inhibits antinociception induced by β-endorphin in mice in response to thermal stimuli when administered at a dose of 65 pmol per animal. In rats, β-endorphin (1-27) does not affect drug-associated place preference when administered at doses up to 20 μg, i.c.v., but inhibits β-endorphin-induced place preference when administered at a dose

β-Endorphin (1-27) (human) acetate (Legacy Tebubio ref. 282T38193L). β-Endorphin (1-27) (human) acetate, existing in the hypophysis cerebri and hypothalamus, exhibits antinociception activity. β-Endorphin (1-27) (human) acetate is an agonist of opioid receptor, showing preferred affinity for μ-opioid receptor and δ-opioid