Activators & Inhibitors

C3a Receptor Agonist (Legacy Tebubio ref. 282T38287). C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestinal ischemia-reperfusion injury. C3aRs are expressed on neural progenitor cells and immature neurons in adult mice. C3a stimulates differentiation of neural progenitor cells in vitro.

Leucomycin A13 (Legacy Tebubio ref. 282T38289). Leucomycin A13 is a macrolide antibiotic and a component of the leucomycin complex originally isolated from S. kitasatoensis. It is active against B. subtilis, S. aureus, M. luteus, and E. coli with MIC values of 0.16, 0.16, 0.08, and >10 μg/ml, respectively. It binds to ribosomes with an IC50 value of 1.2 μM in a radioligand binding assay.

Ginsenoside F3 (Legacy Tebubio ref. 282T3829). Ginsenoside-F3 has immunoenhancing activity by regulating production and gene expression of type 1, type 2 cytokines in murine spleen cells. Ginsenoside-F3 enhances the NF-kappaB DNA binding activity induced by ConA in murine spleen cells (10 μM).

Leucomycin A4 (Legacy Tebubio ref. 282T38290). Leucomycin A4 is a macrolide antibiotic that has been found in S. kitasatoensis. It is active against a variety of bacteria, including S. aureus, B. subtilis, C. diphtheriae, N. gonorrhoeae, and H. influenzae (MICs = 0.15, 1.25, 0.15, 0.6, and 0.15 μg/ml, respectively).

C24 Phytosphingosine (t18:0/24:0) (Legacy Tebubio ref. 282T38291). C24 Phytosphingosine (t18:0/24:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C24 Phytosphingosine (t18:0/24:0) is composed of a phytosphingosine backbone amine-linked to a C24 fatty acid chain. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous penetration and psoriasis in vitro. In a stratum corneum model of healthy skin, the incorporation of long-chain-containing phytoceramides, such as C24 phytosphingosine (t18:0/24:0), increases permeability of the membrane in comparison with incorporation of dihydroceramides.

4-(N-Boc-amino)piperidine (Legacy Tebubio ref. 282T38292). 4-(N-Boc-amino)piperidine is an organic building block.1,2It has been used in the synthesis of aminopiperidine antiviral chemokine (C-C motif) receptor 5 (CCR5) antagonists and antibacterial agents.

4-CPPC (Legacy Tebubio ref. 282T38293). 4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50= 27 μM).1It is selective for MIF-2 over MIF-1 (IC50= 450 μM). It inhibits MIF-2, but not MIF-1, binding to CD74in vitrowhen used at a concentration of 10 μM. 4-CPPC (5, 10, and 25 μM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts.

4-Deoxypyridoxine hydrochloride (Legacy Tebubio ref. 282T38294). 4-Deoxypyridoxine (hydrochloride) inhibits the degradation of intracellular S1P by inhibiting S1P lyase (SPL) activity, minimized the chemically induced apoptosis of insulinoma cell lines as S1P did.

Calpinactam (Legacy Tebubio ref. 282T38295). Calpinactam is a fungal metabolite originally isolated from M. alpina that has antimycobacterial activity. It is active against M. smegmatis (MIC = 0.78 μg/ml) but not a panel of 13 other bacteria and fungi. Calpinactam increases survival in a silkworm model of M. smegmatis infection (ED50 = 5 μg/larva).