Activators & Inhibitors

Alamethicin F50 (Legacy Tebubio ref. 282T38296). Alamethicin F50 is a peptaibol isolated from Trichoderma. It is a polymer of 20 amino acids that includes modified and non-proteinogenic amino acids. Alamethicin F50 is a mixture of 13 different peptides, with the most abundant designated as alamethicin F50/5. Alamethicin F50 forms voltage-dependent ion channels in lipid membranes and acts as a lytic agent. It induces lysis of leukocytes (IC50 = 54 and 80 μM for rat mast cells and mouse spleen lymphocytes, respectively) and exhibits antibacterial activity against a panel of 8 mollicutes (MICs = 1.56-12.5 μM).

Ribavirin-13C5 (Legacy Tebubio ref. 282T38297). Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50= 109.5 μM).4Aerosol administration of ribavirin (30 mg/kg) reduces mortality in a mouse model of influenza A infection.5Formulations containing ribavirin have been used in the treatment of respiratory syncytial virus (RSV), hepatitis C virus (HCV), and viral hemorrhagic fevers.

Tuberculosis inhibitor 3 (Legacy Tebubio ref. 282T38298). Tuberculosis inhibitor 3 (compound 2i) exhibits potent anti-TB properties (MIC < 0.016 μg/mL) against both drug-sensitive and resistant MTB strains, with acceptable pharmacokinetic profiles and oral bioavailability[1].

Tunicamycin V (Legacy Tebubio ref. 282T38299). Tunicamycin 15:1 is a mixture of tunicamycin structural isomers that contains a 15-carbon N-acyl chain with variable branching patterns.

20(R)-Ginsenoside Rg2 (Legacy Tebubio ref. 282T3830). 20(R)-Ginsenoside Rg2 (20R-Ginsenoside Rg2) is a compound with anti-oxidant and anti-apoptosis.

Acetyl-L-Homoserine lactone (Legacy Tebubio ref. 282T38300). Acetyl-L-homoserine lactone belongs to the family of N-acylated homoserine lactones (HSLs) and has an acyl chain length of two carbons. HSLs perform a role in quorum sensing; however, unlike other HSLs, acetyl-L-homoserine lactone does not elicit a response in bacteria. In an assay of carbapenem antibiotic biosynthesis, acetyl-L-homoserine lactone does not induce a response in E. carotovora. In a fluorescence assay using E. coli containing a reporter plasmid of GFP expression in response to exogenous HSLs, acetyl-L-homoserine does not elicit GFP production.

Click N-Acetylmuramic acid - alkyne (Legacy Tebubio ref. 282T38301). Derivative of N-acetylmuramic acid (NAM) component of bacterial peptidoglycans. Incorporated into bacterial peptidoglycans during biosynthesis. Suitable for fluorescent labeling of peptidoglycans when 'click'-conjugated to a fluorescent dye.

Chrysomycin B (Legacy Tebubio ref. 282T38302). Chrysomycin B is an antibiotic isolated from *Streptomyces* sp. that induces DNA damage and inhibits topoisomerase II in the human lung adenocarcinoma (A549) cell line.

Ascr#18 (Legacy Tebubio ref. 282T38304). Ascr#18 is an ascaroside hormone that is expressed throughout nematode development. It exhibits the ability to enhance resistance against a range of infections, including viral, bacterial, oomycete, fungal, and nematode, in Arabidopsis, tomato, potato, and barley[1].