Activators & Inhibitors

L-Homoserine lactone (hydrochloride) (Legacy Tebubio ref. 282T38313). L-Homoserine lactone is a synthetic intermediate.1,2It has been used in the synthesis of organoselenium chemistry intermediates and analogs of bacterial quorum-sensing signaling molecules.

Parvodicin Complex (Legacy Tebubio ref. 282T38314). Parvodicin complex is a mixture of closely related lipophilic glycopeptides originally isolated from A. parvosata. The parvodicin complex has activity against Gram-positive bacteria (MICs = 0.8-12.5 μg/ml) including methicillin-resistant strains of S. aureus (MRSA), S. hemolyticus, and E. faecalis (MICs = 0.1-25 μg/ml). Glycopeptide antibiotics act by preventing cell wall synthesis by binding and sequestering a cell wall precursor with a D-alanine-containing peptide.

Penigequinolone A (Legacy Tebubio ref. 282T38315). Penigequinolone A is produced by Penicillium sp., No. 410 and acts as a pollen growth inhibitor.

ABC34 (Legacy Tebubio ref. 282T38316). ABC34 is an inactive control probe for JJH260 , the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). ABC34 demonstrates an IC50 value greater than 25 μM for the inhibition of 9-PAHSA but is more potent in blocking the serine hydrolase ABHD6 and the palmitoyl-protein hydrolase PPT1, which are both off-targets of JJH260.

Ac-muramic acid (Legacy Tebubio ref. 282T38317). A component of bacterial cell walls. For a protected derivative of MurNAc see Q-1005.

Acetyl Pentapeptide-1 acetate (Legacy Tebubio ref. 282T38318L). Acetyl Pentapeptide-1 acetate is an histone deacetylase inhibitor.

93-O17O (Legacy Tebubio ref. 282T38319). 93-O17O is a chalcogen-containing cationic lipidoid used in the generation of lipid nanoparticles (LPNs). LPNs containing 93-O17O localize to the spleen after intravenous injection into mice and have been utilized for delivering Cre recombinase, ribonucleoproteins for genome editing, and intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens. [1,2,3]

11-O-Galloylbergenin (Legacy Tebubio ref. 282T3832). 11-O-Galloylbergenin is isolated from of Mallotus philippinensis with antioxidant and antiplasmodial activities.

93-O17S (Legacy Tebubio ref. 282T38320). 93-O17S is a chalcogen-containing cationic lipidoid. It has been used in the synthesis of lipid nanoparticles (LPNs) for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice. LPNs containing 93-O17S have been utilized for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens and stimulation of interferon genes [STING] activation in a B16/F10 murine melanoma model.