Activators & Inhibitors

Rucaparib, also known as AG-014699 or PF-01367338, is an inhibitor of PARP1 with Ki of 1.4 nM.

Rucaparib, also known as AG-014699 or PF-01367338, is an inhibitor of PARP1 with Ki of 1.4 nM.

Rucaparib, also known as AG-014699 or PF-01367338, is an inhibitor of PARP1 with Ki of 1.4 nM.

S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 µM. It has anti-inflammatory and anti-depressant activity in the central nervous system.

S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 µM. It has anti-inflammatory and anti-depressant activity in the central nervous system.

S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 µM. It has anti-inflammatory and anti-depressant activity in the central nervous system.

Potent CREBBP/EP300 bromodomain inhibitor

Potent CREBBP/EP300 bromodomain inhibitor

SGI-1776 is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival. Through extensive biomedical characterization, SGI-1776 exhibits specificity to the three isoforms of the Pim family, including Pim-1, Pim-2, and Pim-3. Treatment with SGI-1776 induces apoptosis in CLL primary cell line.