Activators & Inhibitors

Guanosine 5'-triphosphate sodium salt hydrate (GTP) functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways.

Guanosine 5'-triphosphate sodium salt hydrate (GTP) functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways.

3-aminobenzamide is a novel, potent inhibitor of PARP. Also acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.

3-aminobenzamide is a novel, potent inhibitor of PARP. Also acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.

Activity: PPARγ partial agonist . Function/Pharmacology: Displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. Highly effective (30 nM) at blocking Cdk5-mediated phosphorylation of PPARγ. Cell permeable. Chemical Name: (S)-2-(3-((1-(4-Methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl)methyl)phenoxy)propanoic acid

Stemolecule CHIR99021 (2 mg)

Polyethylene glycol Water-soluble and non-toxic polymer. Increases solubility of therapeutic proteins and peptides.

Stemolecule LDN-193189 (2 mg)

Activity: Tankyrase inhibitor, Cardiomyogenesis inducer . Function/Pharmacology: Tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively). Antagonizes wnt signaling via stimulation of ß-catenin degradation and stabilization of actin.1 Robustly induces cardiomyogenesis of stem cells.2 Cell Permeable Chemical Name: 2-[4-(Trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol