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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 70851 )

      • LY 178002

        Ref: T15825
        Sizes: 25 mg, 100 mg, 50 mg
        From: €1,726.00

        LY 178002 (Legacy Tebubio ref. 282T15825). LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of LTB4 by human polymorphonuclear leukocytes and displays relatively weak inhibition on cyclooxygenase.

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      • Lometrexol

        Ref: T15826
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €92.00

        Lometrexol (Legacy Tebubio ref. 282T15826). Lometrexol (LY 264618), an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and Apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.

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      • LY 345899

        Ref: T15827
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €46.00

        LY 345899 (Legacy Tebubio ref. 282T15827). LY 345899 is a folate analog that inhibits methylenetetrahydrofolate dehydrogenase and MTHFD2, with IC50 values of 96 nM and 663 nM, respectively, and a Ki of 18 nM for MTHFD1.

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      • L 888607

        Ref: T15828
        Sizes: 5 mg, 1 mL * 10 mM (in DMSO)
        From: €356.00

        L 888607 (Legacy Tebubio ref. 282T15828). L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM).

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      • L 888607 Racemate

        Ref: T15829
        Sizes: 25 mg, 100 mg, 50 mg
        From: €1,226.00

        L 888607 Racemate (Legacy Tebubio ref. 282T15829). L 888607 Racemate is a selective antagonist of the prostaglandin D2 receptor subtype 1 (DP1) with Ki values of 132 nM and 17 nM for DP1 and the thromboxane A2 receptor (TP), respectively.

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      • Naproxen sodium

        Ref: T1582L
        Sizes: 1 g, 1 mL * 10 mM (in DMSO)
        From: €39.00

        Naproxen sodium (Legacy Tebubio ref. 282T1582L). Naproxen sodium (Anaprox) is a COX inhibitor for COX-1 and COX-2 with analgesic and antipyretic properties.

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      • Vorinostat

        Ref: T1583
        Sizes: 1 g, 500 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €50.00

        Vorinostat (Legacy Tebubio ref. 282T1583). Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and induces apoptosis.

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      • M-110

        Ref: T15830
        Sizes: 5 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €66.00

        M-110 (Legacy Tebubio ref. 282T15830). M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases, showing a preference for PIM-3 (IC50=47 nM), and inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 also inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM.

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      • M-525

        Ref: T15831
        Sizes: 25 mg, 100 mg, 50 mg
        From: €2,747.00

        M-525 (Legacy Tebubio ref. 282T15831). M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, irreversible, and covalent menin-MLL protein-protein interaction inhibitor. It has an Anti-leukemia activity.

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