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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 70847 )

      • ML132

        Ref: T16105
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg
        From: €507.00

        ML132 (Legacy Tebubio ref. 282T16105). ML132 is an effective and selective inhibitor of caspase 1 (IC50: 0.316 nM).

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      • ML224

        Ref: T16106
        Sizes: 1 mg, 5 mg, 25 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €60.00

        ML224 (Legacy Tebubio ref. 282T16106). ML224 (NCGC00242364) is a TSHR antagonist for the treatment of Graves' orbital disease and Graves' hyperthyroidism.

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      • ML230

        Ref: T16107
        Sizes: 5 mg, 10 mg
        From: €1,011.00

        ML230 (Legacy Tebubio ref. 282T16107). ML230 is a selective ATP-binding cassette (ABC) transporter ABCG2 inhibitor. It 36-fold selective for ABCG2 over ABCB1 (EC50s: 0.13 μM and 4.65 μM, respectively).

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      • ML349

        Ref: T16108
        Sizes: 1 mg, 5 mg, 25 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €35.00

        ML349 (Legacy Tebubio ref. 282T16108). ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).

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      • ML402

        Ref: T16109
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €36.00

        ML402 (Legacy Tebubio ref. 282T16109). ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.

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      • Isotretinoin

        Ref: T1611
        Sizes: 100 mg, 50 mg, 200 mg
        From: €41.00

        Isotretinoin (Legacy Tebubio ref. 282T1611). Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs), which act as transcription factors that promote cell differentiation and apoptosis. This naturally occurring retinoic acid has potential antineoplastic activity, exhibits immunomodulatory and anti-inflammatory responses, and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.

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      • ML418

        Ref: T16110
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €38.00

        ML418 (Legacy Tebubio ref. 282T16110). ML418 is a potent, selective, and CNS-penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM) that also effectively inhibits Kir6.2/SUR1.

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      • ML604086

        Ref: T16111
        Sizes: 1 mg, 5 mg, 25 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €69.00

        ML604086 (Legacy Tebubio ref. 282T16111). ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations. ML604086 is a selective inhibitor of CCR8. It also inhibiting CCL1 binding to CCR8 on circulating T-cells.

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      • ML67-33

        Ref: T16112
        Sizes: 25 mg, 100 mg, 50 mg, 2 mg
        From: €167.00

        ML67-33 (Legacy Tebubio ref. 282T16112). ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels.

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