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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 70847 )

      • ML753286

        Ref: T16113
        Sizes: 25 mg, 100 mg, 50 mg
        From: €1,726.00

        ML753286 (Legacy Tebubio ref. 282T16113). ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (IC50: 0.6 μM). It is also stable in plasma across species.

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      • Pavinetant

        Ref: T16114
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €84.00

        Pavinetant (Legacy Tebubio ref. 282T16114). Pavinetant (MLE-4901) is an orally available neurokinin-3 receptor (NK3R) antagonist used to improve menopausal symptoms.

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      • MLi-2

        Ref: T16115
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €69.00

        MLi-2 (Legacy Tebubio ref. 282T16115). MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM).

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      • MLN-4760

        Ref: T16116
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg
        From: €213.00

        MLN-4760 (Legacy Tebubio ref. 282T16116). MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).

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      • Pevonedistat hydrochloride

        Ref: T16117
        Sizes: 1 mg, 5 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €55.00

        Pevonedistat hydrochloride (Legacy Tebubio ref. 282T16117). Pevonedistat hydrochloride (MLN4924 hydrochloride) is a selective and potent NEDD8 activating enzyme inhibitor (IC50: 4.7 nM) that induces apoptosis and cell cycle inhibition in cancer cells, and is used in the study of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Pelubiprofen has been used in the study of AML and MDS.)

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      • MLS0315771

        Ref: T16118
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €55.00

        MLS0315771 (Legacy Tebubio ref. 282T16118). MLS0315771 is an effective and biologically active competitive phosphomannose isomerase (MPI) inhibitor (IC50: ~1 μM and a Ki: 1.4 μM).

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      • MLT-747

        Ref: T16119
        Sizes: 25 mg, 100 mg, 50 mg
        From: €1,294.00

        MLT-747 (Legacy Tebubio ref. 282T16119). MLT-747 is an effective and allosteric inhibitor of MALT1. It binds MALT1 in the allosteric Trp580 pocket (IC50: 14 nM).

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      • Neostigmine methyl sulfate

        Ref: T1612
        Sizes: 100 mg, 200 mg
        From: €57.00

        Neostigmine methyl sulfate (Legacy Tebubio ref. 282T1612). Neostigmine methyl sulfate (Syntostigmin) is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.

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      • MLT-748

        Ref: T16120
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €114.00

        MLT-748 (Legacy Tebubio ref. 282T16120). MLT-748 is a MALT1 allosteric inhibitor that inhibits the growth of lung cancer cells. MLT-748 acts by blocking the protein hydrolyzing activity of MALT1.

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