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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 70846 )

      • MMG-11

        Ref: T16123
        Sizes: 2 mg
        From: €66.00

        MMG-11 (Legacy Tebubio ref. 282T16123). MMG-11 inhibits both TLR2/1 and TLR2/6 signaling (IC50s: 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses). MMG-11 is an effective and selective human TLR2 antagonist with low cytotoxicity.

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      • MMP13-IN-3

        Ref: T16124
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €102.00

        MMP13-IN-3 (Legacy Tebubio ref. 282T16124). MMP13-IN-3 is >1000 selective over other MMPs. MMP13-IN-3 is an effective, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis.

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      • MMV390048

        Ref: T16125
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €40.00

        MMV390048 (Legacy Tebubio ref. 282T16125). MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns.

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      • Monepantel

        Ref: T16126
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €102.00

        Monepantel (Legacy Tebubio ref. 282T16126). Monepantel (AAD1566) is an organic anthelmintic and nicotinic acetylcholine receptor antagonist from roundworms and esophagostomies that is widely used for de-worming in agriculture and livestock.

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      • Moricizine

        Ref: T16127
        Sizes: 25 mg, 100 mg, 50 mg
        From: €1,726.00

        Moricizine (Legacy Tebubio ref. 282T16127). Moricizine is an antiarrhythmia agent which is used primarily for ventricular rhythm disturbances.

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      • MP-A08

        Ref: T16128
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg
        From: €38.00

        MP-A08 (Legacy Tebubio ref. 282T16128). MP-A08 is a highly selective, ATP-competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 [Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively].

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      • MPI_5a

        Ref: T16129
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €316.00

        MPI_5a (Legacy Tebubio ref. 282T16129). MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM).

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      • Hydralazine hydrochloride

        Ref: T1613
        Sizes: 1 g, 500 mg, 200 mg
        From: €41.00

        Hydralazine hydrochloride (Legacy Tebubio ref. 282T1613). Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume, and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells.

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      • Mps1-IN-3

        Ref: T16130
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 2 mg, 1 mL * 5 mM (in DMSO)
        From: €40.00

        Mps1-IN-3 (Legacy Tebubio ref. 282T16130). Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).

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