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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 70846 )

      • MRS 1754

        Ref: T16140
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg
        From: €44.00

        MRS 1754 (Legacy Tebubio ref. 282T16140). MRS 1754 is a selective antagonist radioligand for the A2B adenosine receptor, exhibiting very low affinity for A1 and A3 receptors in both humans and rats.

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      • MRT00033659

        Ref: T16141
        Sizes: 5 mg, 2 mg
        From: €78.00

        MRT00033659 (Legacy Tebubio ref. 282T16141). MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization.

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      • MRTX-1257

        Ref: T16143
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €66.00

        MRTX-1257 (Legacy Tebubio ref. 282T16143). MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS-dependent ERK phosphorylation in H358 cells. MRTX-1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above cellular potency, and 77% target engagement in a PK/PD experiment.

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      • MRX-2843

        Ref: T16144
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €67.00

        MRX-2843 (Legacy Tebubio ref. 282T16144). MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively).

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      • MS-444

        Ref: T16145
        Sizes: 1 mg, 25 mg, 100 mg, 50 mg, 2 mg
        From: €709.00

        MS-444 (Legacy Tebubio ref. 282T16145). MS-444 (BE-34776) is a smooth muscle myosin light chain kinase (MLCK) and HuR inhibitor with antitumor activity for triple-negative breast and colorectal cancer.

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      • Irbesartan

        Ref: T1615
        Sizes: 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €54.00

        Irbesartan (Legacy Tebubio ref. 282T1615). Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker whose mechanism of action involves antagonizing the Angiotensin 2 Receptor.

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      • Betamethasone 17-benzoate

        Ref: T16152
        Sizes: 25 mg
        Price Enquiry

        Betamethasone 17-benzoate (Legacy Tebubio ref. 282T16152). Betamethasone 17-benzoate, a representative steroid, is used in the treatment of recurrent aphthous ulcers (RAU).

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      • MS4078

        Ref: T16153
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €50.00

        MS4078 (Legacy Tebubio ref. 282T16153). MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.

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      • MS417

        Ref: T16154
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 2 mg
        From: €35.00

        MS417 (Legacy Tebubio ref. 282T16154). MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP BRD with IC50 of 32.7 μM.

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