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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 70847 )

      • Nonaethylene glycol monododecyl ether

        Ref: T16335
        Sizes: 1 g, 100 mg, 50 mg, 500 mg, 1 mL * 10 mM (in DMSO)
        From: €35.00

        Nonaethylene glycol monododecyl ether (Legacy Tebubio ref. 282T16335). Nonaethylene glycol monododecyl ether (Polidocanol) is a nonionic surfactant and polyethylene glycol (PEG) detergent. It can be used to form initial coalesced O/W emulsion droplets and for protein separation and purification.

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      • Norgestimate metabolite Norelgestromin

        Ref: T16338
        Sizes: 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €33.00

        Norgestimate metabolite Norelgestromin (Legacy Tebubio ref. 282T16338). Norgestimate metabolite Norelgestromin (17-Deacylnorgestimate) is one of the active metabolites of norgestimate.It is a steroidal progestin used in contraceptive patches, where it is combined with the estrogen ethinyl estradiol.

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      • Norverapamil hydrochloride

        Ref: T16339
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €36.00

        Norverapamil hydrochloride (Legacy Tebubio ref. 282T16339). Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.

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      • Glibenclamide

        Ref: T1634
        Sizes: 1 g, 500 mg, 1 mL * 10 mM (in DMSO)
        From: €52.00

        Glibenclamide (Legacy Tebubio ref. 282T1634). Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.

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      • Nosiheptide

        Ref: T16340
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €70.00

        Nosiheptide (Legacy Tebubio ref. 282T16340). Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by *Streptomyces actuosus*, is a potent feed additive that promotes animal growth by inhibiting bacterial protein synthesis. It is characterized by an indole side ring system and regiospecific hydroxyl groups on its macrocyclic core.

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      • Notch inhibitor 1

        Ref: T16341
        Sizes: 25 mg, 100 mg, 50 mg
        From: €3,088.00

        Notch inhibitor 1 (Legacy Tebubio ref. 282T16341). Notch inhibitor 1 is an effective Notch inhibitor (IC50s: 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively). Notch inhibitor 1 is also used in the research of cancer.

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      • KL1333

        Ref: T16342
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €108.00

        KL1333 (Legacy Tebubio ref. 282T16342). KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.

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      • NRC-2694

        Ref: T16343
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €88.00

        NRC-2694 (Legacy Tebubio ref. 282T16343). NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.

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      • NS-2028

        Ref: T16344
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €38.00

        NS-2028 (Legacy Tebubio ref. 282T16344). NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity) commonly used in nitric oxide signaling pathway research. It inhibits sGC activity in mouse cerebellum homogenates and neuronal NO synthase (IC50: 17 nM and 20 nM), inhibits 3-morpholino-sydnonimine (SIN-1)-elicited cyclic GMP formation in human cultured umbilical vein endothelial cells (IC50: 30 nM), and completely inhibits NO-dependent relaxant responses in non-vascular smooth muscle (1 μM). NS-2028 also decreases vascular endothelial growth factor-induced angiogenesis and permeability.

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