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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 70847 )

      • PF-3882845

        Ref: T16502
        Sizes: 1 mg, 5 mg, 25 mg, 50 mg, 10 mg
        From: €97.00

        PF-3882845 (Legacy Tebubio ref. 282T16502). PF-3882845 is an orally available and selective salicorticoid receptor (MR) antagonist that binds to the progesterone receptor (PR) and can be used to study endocrine diseases and urogenital disorders.

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      • PF-4191834

        Ref: T16503
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €55.00

        PF-4191834 (Legacy Tebubio ref. 282T16503). PF-4191834 is a noniron chelating and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) with an IC50 of 229 nM. PF-4191834 shows ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX and displays no activity toward the cyclooxygenase enzymes. PF-4191834

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      • PF-4693627

        Ref: T16504
        Sizes: 1 mg, 5 mg, 10 mg, 500 μg
        From: €106.00

        PF-4693627 (Legacy Tebubio ref. 282T16504). PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).

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      • PF-4778574

        Ref: T16505
        Sizes: 25 mg, 100 mg, 50 mg
        From: €2,066.00

        PF-4778574 (Legacy Tebubio ref. 282T16505). PF-4778574 is a positive AMPA receptor allosteric modulation (EC50: 45 to 919 nM in different cells).

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      • PF-4878691

        Ref: T16506
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €46.00

        PF-4878691 (Legacy Tebubio ref. 282T16506). PF-4878691 (3M-852A) is a potent and selective Toll-like receptor 7 agonist, designed to dissociate its antiviral and inflammatory activities.

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      • PF-5006739

        Ref: T16507
        Sizes: 2 mg
        From: €88.00

        PF-5006739 (Legacy Tebubio ref. 282T16507). PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner.

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      • PF-5190457

        Ref: T16508
        Sizes: 1 mg, 5 mg, 25 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €36.00

        PF-5190457 (Legacy Tebubio ref. 282T16508). PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).

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      • PF-610355

        Ref: T16509
        Sizes: 1 mg, 5 mg
        From: €719.00

        PF-610355 (Legacy Tebubio ref. 282T16509). PF-610355 is a long-acting and potent β2-adrenergic receptor agonist (EC50: 0.26 nM).PF-610355 can be used to study asthma and COPD.

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      • PF-610355 HCl

        Ref: T16509L
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg
        From: €108.00

        PF-610355 HCl (Legacy Tebubio ref. 282T16509L). PF-610355 HCl is a selective and potent β2-adrenergic receptor agonist, a bronchodilator, and is used in the study of asthma and chronic obstructive pulmonary disease.

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