Results for Antibiotics & Metabolites ( 219 )
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Activity: Resveratrol metabolite . Function/Pharmacology: Metabolite of resveratrol produced by gut microbiota.1-3 Glucoronide conjugates are found in human urine after oral intake of resveratrol-containing dietary supplements.4 Dihydroresveratrol glucoside is a potent melanogenesis inhibitor in B16F0 melanoma cells.5 Inactive analog of resveratrol in induction of premature senescence.6 Chemical Name: 5-[2-(4-Hydroxyphenyl)ethyl]-1,3-benzenediol; 3,4′,5-trihydroxybibenzyl
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Activity: Remdesivir active metabolite . Function/Pharmacology: Parent nucleoside and active metabolite of the SARS-CoV2 drug remdesivir. Displayed broad spectrum antiviral activity against HCV, YFV, DENV-2, influenza A, parainfluenza 3, and SARS-CoV.1 It has been suggested that GS-441524 is superior as an anti-SARS-CoV2 drug due to simplicity of preparation compared to remdesivir, lack of on-target liver toxicity, and the fact that remdesivir is prematurely hydrolyzed to GS-441524 in human serum.2 Additionally, the enzymes that hydrolyze remdesivir to active metabolite GS-441524 are hardly expressed in lungs. Chemical Name: (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile