Compound Libraries

- A collection of 127 phosphatase inhibitors with known activity; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - NMR and HPLC validated to ensure high purity and quality.

- A unique collection of 4921 approved and clinical drugs for high throughput screening (HTS) and high content screening (HCS); - An effective tool for discovering new with old drugs, cell induction, and new drug target screening; - All approved drugs collected in this library are approved by Food and Drug Administration (FDA), the European Medicine Agency (EMA), or National Medical Products Administration (NMPA), or included in the US Pharmacopeia (USP) Dictionary, the British Pharmacopoeia (BP), the European Pharmacopoeia (EP), the Japanese Pharmacopoeia (JP), or Chinese Pharmacopoeia (CP) Dictionary; - Covers various research areas, such as cancer, cardiovascular disease, immunology, respiratory system, etc. - Covers various targets, such as 5-HT Receptor, Sodium Channel, p38 MAPK, PI3K, MEK, etc. - Detailed compound information with structure, target, activity, and brief introduction; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure

- 210 macrocyclic compounds of known activity for high-throughput, high-content screening; - A powerful tool for studying antibacterial, antiviral, and protein-protein interactions, etc.; - Most of them are already approved, with information regarding biosafety and biological activity; - NMR and HPLC validated to ensure high purity and quality; - All compounds are available from stock supplies.

- A unique collection of 485 PPI-related compounds for drug screening; - Targets include PD-1/PD-L1, Bcl-2, BET bromodomain, BRD4 bromodomain, etc. - Detailed compound information with structure, target, and biological activity description; - NMR and HPLC validated to ensure high purity and quality.

- A unique collection of 2400 covalent Inhibitors and other molecules with common warheads like chloroacetyl，2-Chloropropionyl，Acryloyl，sulfonyl fluoride, alkyne，acrylamide, ketocarbonyl，disulfide bond, etc. - Structurally diverse with some covalent inhibitors approved by the FDA - Detailed compound information with structure, target, IC50, and biological activity description - NMR and HPLC/LCMS validated to ensure high purity

The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. In recent years, covalent chemical probes have become an important tool for drug discovery. A large number of successful applications in the evaluation of protein druggability, especially the successful application of Cys residues, bring hope for the discovery and synthesis of new covalently modified compounds. To this end, we designed a cysteine-specific covalent library. The electrophilic "warhead" of the fragments is acrylamide or chloroacetamid

- 76 exosome-related compounds that can be used for high-throughput and high-content screening. - Detailed instructions, compound structures, target information, activity descriptions, etc. - NMR and HPLC analytical techniques to ensure high product purity and quality. - All compounds are available in stock.

- A unique collection of 1796 annotated bioactive compounds with clear targets, suitable for phenotypic screening； - Cover more than 600 drug targets, Structurally diverse； - 2-4 structurally diversified compounds for the same annotated 'on-target' to increase the success rate of target identification (enables the generation of much stronger target–phenotype hypotheses); - Detailed information about compound structure, target, activity, etc.； - NMR and HPLC/LCMS validated to ensure high purity and quality.

- A unique collection of 223 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS); - Targets include GRP78, IRE1, ATF6, PERK, etc. - Some compounds have been approved by FDA; - Structurally diverse, medicinally active, and cell permeable; - Rich documentation with chemical structure, target, and bioactivity information; - NMR and HPLC validated to ensure high purity.