Lipids

20-(Bromoacetamido-PEG5-ethylcarbamoyl)nonadecanoic-t-butyl ester is a PEG linker with a bromine and an alkane tail that has a terminal t-butyl ester group. The bromine (Br) can be used as a leaving group for nucleophilic substitution reactions. The t-butyl group can be deprotected under acidic conditions. The polymer can form micelles spontaneously in water. It may also be used to prepare more complex lipids for nanoparticles for drug delivery. Reagent grade, for research purpose.

DSPE-PEG-endo-BCN, MW 5,000 is a phospholipid PEG polymer which can be used to encapsulate drugs/therapeutics agents in targeted drug delivery system, such as liposome based mRNA vaccine. The BCN group enables copper free click chemistry with azide-tagged molecules. Reagent grade, for research purpose.

DBCO-PEG-tBoc, MW 3,400 is an azide reactive PEGylation reagent. DBCO reacts with azide (N3) efficiently without the presence of Cu catalyst, which is known to be highly toxic for cells. Under mild acidic conditions, t-Boc group can be removed to yield the free amine. Reagent grade, for research purpose.

BP Lipid 229 is an amino ionizable lipid. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C7 position relative to the amine nitrogen. The primary lipid tail has 8 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

18-(Azide-PEG3-ethylcarbamoyl)heptadecanoic-t-butyl ester is a PEG linker with an azide group and an alkane tail that has a terminal t-butyl ester group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl group can be deprotected under acidic conditions. The polymer can form micelles spontaneously in water. It may also be used to prepare more complex lipids for nanoparticles for drug delivery. Reagent grade, for research purpose.

m-PEG-Vinylsulfone, MW 10,000 polyPEG with a terminal vinyl sulfone group. The vinyl sulfone is reactive with thiol molecules via thiol-ene reaction for bioconjugation. Reagent grade, for research purpose.

20-(Amine-PEG3-ethylcarbamoyl)nonadecanoic-t-butyl ester has an amine group on a PEG linker with a alkane tail that has a t-butyl ester group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The t-butyl group can be deprotected under acidic conditions. It is is a self-assembling PEG reagent which may form micelles in water. This compound may also be used as a building block for lipids in nanotechnolgy and drug delivery. Reagent grade, for research purpose.

20-(Bromoacetamido-PEG3-ethylcarbamoyl)nonadecanoic acid has a bromine on a PEG linker with an alkane tail that has a carboxylic acid group. The bromine (Br) can be used as a leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. It is a self-assembling PEG reagent which may form micelles in water. This compound may also be used as a building block for lipids in nanotechnolgy and drug delivery. Reagent grade, for research purpose.

Fmoc-Gly-Gly-Phe-Gly-OH is a self-assembly of N- and C-protected tetrapeptide containing an Fmoc-protected amino group. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The compound is a protease cleavable linker used for antibody-drug conjugates (ADCs). Reagent grade, for research purpose.