Lipids

DSPE-PEG-DBCO, MW 2,000 is a PEG lipid conjugate featuring a DSPE phospholipid and a DBCO group. DSPE is a saturated phospholipid that is commonly used to prepare lipid nanoparticles in drug delivery, while DBCO is a click chemistry handle that is frequently used to conjugate with azides on target molecules to form stable triazole linkages.

MC-Val-Cit-PAB-SN38 is a cleavable ADC linker featuring a maleimide, a Val-Cit dipeptide, a PAB group and an SN38 warhead. Maleimide is a covalent ligand used for linking thiols such as those in cysteines residues in proteins, while the Val-Cit-PAB motif is an enzyme-cleavable linker. This linker efficiently releases the toxin, SN38, to target cells to cause cellular apoptosis.

BP Lipid 311 is a branched amino lipid featuring a dimethylamino headgroup, esters of a palmitoleic acid group and an aliphatic acetal. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Desthiobiotin-PEG3-Amine is a short PEG linker featuring a primary amine and a desthiobiotin group. Primary amines readily form amides with carboxylic acids in the presence of coupling reagents such as HATU or EDC. Desthiobiotin is used for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins.

JQ1 carboxylic acid serves as a potent BET bromodomain inhibitor. It features a carboxylic acid functional group, making it suitable for conjugation reactions.

Biotin-PEG4-Amide-PEG8-Amine is a PEG linker featuring a primary amine and a biotin group. Primary amines readily form amides with carboxylic acids in the presence of coupling reagents such as HATU or EDC. Biotin is used for affinity-based applications such as pull-down assays or for ligating with avidin proteins.

DSPE-Amide-PEG-Rhodamine, MW 2,000 is a PEG lipid with a DSPE group and a Rhodamine fluorophore. DSPE is a phospholipid that is known to spontaneously form micelles in water and is featured heavily in lipid nanoparticles and drug development. Rhodamine is a fluorescent dye with excitation and emission maxima at 570 and 595 nm respectively.

3-Hydroxy-2-(hydroxymethyl)propyl (9Z)-9-hexadecenoate is a lipid intermediate featuring a palmitoleate ester linked to a branched central carbon with two free primary alcohols. A compound like this may be employed in the development of lipid nanoparticles for drug delivery.

3-[4,4-Bis(octyloxy)-1-oxobutoxy]-2-(hydroxymethyl)propyl (9Z)-9-hexadecenoate is a lipid molecule featuring a primary alcohol, a palmitoleic acid, and a butanoic acid linked to two C8 chains via an acetal. Compounds such as this may also be used as intermediates in building lipids for use in lipid nanoparticles.