Lipids

BP Lipid 313 is an ionizable lipid analogue of ALC-0315 featuring an ethanolamine head and two carbamate tails, one being an undecyl tail and the other being a branched C17. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is cleavable by cell proteases and features a carboxylic acid which is free for coupling reactions with amines to form amides. The Boc can be removed under acidic conditions to reveal a free primary amine, which may be used in a variety of reactions such as coupling or reductive amination.

This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as click chemistry, in the presence of a copper (Cu)-containing catalyst. Alkyne cholesterol represents a versatile, sensitive, and easy-to-use tool for tracking cellular cholesterol metabolism and localization as it allows for manifold detection methods including mass spectrometry, and fluorescence microscopy.

This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as click chemistry, in the presence of a copper-containing catalyst. Alkyne cholesterol represents a versatile, sensitive, and easy-to-use tool for tracking cellular cholesterol metabolism and localization as it allows for manifold detection methods including mass spectrometry, and fluorescence microscopy.

This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as click chemistry, in the presence of a copper (Cu)-containing catalyst. E-Cholesterol Alkyne (19-ethynylcholesterol) represents a versatile, sensitive, and easy-to-use tool for tracking cellular cholesterol metabolism and localization as it allows for manifold detection methods including mass spectrometry, and fluorescence microscopy.

2-(7Z,10Z)-7,10-Hexadecadien-1-yloxirane is an intermediate for the preparation of lipid molecules. It features a polyunsaturated chain with an epoxy ring that can be opened by nucleophiles.

Azido-PEG8-diglycoamide-Lys(Boc)-PAB is a PEG labeling reagent featuring an azide, a Val-Lys dipeptide, and a PAB group. Azides are highly reactive in click chemistry with terminal alkynes and strained cyclooctynes while the Val-Lys dipeptide is enzyme cleavable and triggers payload release via an elimination mechanism within the PAB structure. Finally, the ε-amine of the lysine is Boc-protected.

Azido-PEG8-triethoxysilane is a short PEG linker featuring an azide, which is used in click chemistry with alkynes, and a triethoxysilane group, which may be used to retain a compound on silica surfaces such as those used in normal phase chromatography.

DOPE-PEG-Fluor 555, MW 5,000 is a PEG lipid featuring a DOPE phospholipid and a Fluor 555 dye. DOPE is an unsaturated phospholipid that features prominently in the development of lipid nanoparticles while Fluor 555 is a bright orange cyanine dye that can be used in fluorescence microscopy, FRET and other in vivo imaging techniques.