Lipids

BP Lipid 316 is an ionizable lipid analogue of DLin-MC3-DMA featuring a 4-(dimethylamino)butanoate head, two linoleic acid tails, and one primary alcohol. The alcohol may be used to further derivatize this compound. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

3-Arm PEG4-Azide is a homotrifunctional PEG linker containing three azides, which can be used in click chemistry with terminal alkynes and strained cyclooctynes like DBCO and BCN. The use of PEG linkers over their alkane counterparts provides high aqueous solubility and alters in vivo pharmacodynamics.

DOPE-PEG-Cy5.5, MW 2,000 is a PEG-lipid-dye conjugate featuring a DOPE phospholipid and a Cy5.5 dye. DOPE is featured prominently in lipid nanoparticles for its ability to readily form micelles while Cy5.5 is a fluorescent dye which is used in histology, FRET and other fluorescence-based assays in vivo.

ZXH 3-26 degrades BRD4 while not exhibiting any significant degradation of BRD2 or BRD3. This product is ready for conjugation to target proteins for PROTAC R&D. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

3,4-(PEG4-Azide)-2-((PEG4-Azide)methyl)propan-1-ol is a multifunctional reagent combining three azides and a primary alcohol. The azide group is commonly used in click chemistry for reactions with terminal alkynes as well as strained cyclooctynes such as BCN or DBCO. The primary alcohol is a useful scaffold for building molecular complexity such as for creating esters or substitution with any number of functional groups. The use of a PEG linker increases this compound’s aqueous solubility, altering its DMPK properties in drug development.

Mes-PEG2-CH2-t-butyl ester is a PEG linker consisting of a PEG2 linker for improved water-solubility of the compound and a t-butyl ester group which can be deprotected under acidic conditions. The mesylate serves as an excellent leaving group, offering all the advantages without the limitation of having an acidic proton that could react with nucleophiles.

2-(bromomethyl)-2-(hydroxymethyl)propane-1,3-(9Z,12Z)-dioctadeca-9,12-dienoate is a chemical reagent featuring a bromide, a primary alcohol, and two identical esters coupled to unsaturated C18 tails. Bromide is easily displaced by nucleophiles in substitution reactions, while alcohols may be used in a wide variety of reactions. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

DOPE-PEG-Cy5.5, MW 5,000 is a PEG-lipid-dye conjugate featuring a DOPE phospholipid and a Cy5.5 dye. DOPE is featured prominently in lipid nanoparticles for its ability to readily form micelles while Cy5.5 is a fluorescent dye which is used in histology, FRET and other fluorescence-based assays in vivo.

2-(bromomethyl)-1,2,3-(9Z)-trioctadeca-9-enoate is a chemical reagent featuring a bromide and three identical esters coupled to unsaturated C18 tails. Bromide is easily displaced by nucleophiles in substitution reactions. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.