Lipids

11-A-M is an ionizable lipid used in lipid nanoparticles(LNPs). LNP compositions have proven effective as transport vehicles into cells and/or intracellular compartments for biologically active substances such as small molecule drugs proteins and nucleic acids. This lipid can deliver siRNA and sgRNA to T cells.

Tri-GalNAc(OAc)3 TFA

1-Palmitoyl-2-(Propargylacetyl)-Sn-Glycero-3-Phosphocholine is a phosphocholine containing an azide-reactive propargyl on one of its tails and a positively charged quaternary amine head.

Fluorescein-PEG5-Methyltetrazine is a xanthene dye with excitation/emission maximum of 494/517 nm and a terminal tetrazine group. The terminal methyltetrazine enables fast click reactions with TCO (trans-cycloctene). Hydrophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. Reagent grade, for research use only. Please contact us for GMP-grade inquiries.

Phosphatidylethanol (16:0 LysoPEth) is formed primarily in the liver by transphosphatidylation of phosphatidylcholine (PC) by phospholipase D in the presence of ethanol. PEth is a long-lived circulating ethanol biomarker with forensic and biomedical applications. LysoPEth is formed either through loss of the sn-1 acyl chain or transphosphatidylation of LysoPC. It is also reported to be a biomarker of alcohol consumption.

Lipid A monophosphoryl from Salmonella minnesota R595

DOG-IM4 is an ionizable lipid which is used to deliver mRNA by forming lipid nanoparticles (LNPs). DOG-IM4 can improve the thermostability of mRNA/LNP in combination with helper lipids.

Lipid CP-LC-0741 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo, with no signs of toxicity.

Lipid CP-LC-1073 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo. Moreover, using a typical LNP formulation (IL/Ch/DOPE/PEG: 50/38.5/10/1.5), it has shown to induce specific lung targeting much more efficiently that other commercial alternatives through IV injection, with no signs of toxicity.