Lipids

Vacuolin-1 is a triazine-based chemical that inhibits Ca2+-dependent lysosomal exocytosis by preventing lysosome fusion with the plasma membrane. It uniquely targets this process without affecting other organelles or endocytic/secretory traffic. Widely utilized in research, Vacuolin-1 helps study lysosomal content release and autophagy modulation.

A useful synthetic scaffold for ionizable lipids featuring one branched and one oleic fatty acid tail. A free hydroxyl is available for further functionlization. Reagent grade, for research purpose. Please contact us for GMP-grade.

Mal-PEG12-MMAE acts as a linker attached to a payload, where the maleimide group will react with a thiol group to form a covalent bond, and the MMAE payload serves as a synthetic antineoplastic agent for targeted therapeutics. The PEG12 units elevate the molecule's water solubility.

DBCO-PEG12-TFP ester acts as a bifunctional PEG linker with a DBCO group that can be used for copper-free Click Chemistry reactions and TFP ester, which is less susceptible to undergo hydrolysis compared to NHS ester. The solubility of the compound in aqueous media is elevated via the PEG linkage.

Clickable Cholic acid

Clickable Chenodeoxycholic acid

18:0 propargyl PC

18:1 propargyl PC

16:0 propargyl SM (d18:1-16:0)