PEG

2-Amino-1,3-bis(t-butoxycarbonylethoxy)propane is a PEG linker containing an amino group with two t-butyl esters. The amino group is reactive with carboxylic acids, activated NHS esters. The t-butyl protected carboxyl groups can be deprotected under acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Trifluoroacetamidoethyl-SS-propionic NHS ester is a cleavable linker containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The disulfide bond can be cleaved under reduction conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Thalidomide-O-PEG4-Propargyl is synthesized compound that incorporatess the Thalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology, Propargyl is reactive with azide molecule in the presence of Cu catalyst. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-(triethoxysilane-PEG36-PEG3-)-N-bis(PEG3-biotin) is a PEG linker containing a triethoxysilane moiety and a pair of biotin groups. Triethoxysilane is commonly used for surface modifications. The biotinylation can react with amine molecules in the presence of activator EDC or HATU. PEG attached to the biotin gives an extended spacer arm that permits the biotin to reach into the binding pocket of the protein. The PEG moiety also increases solubility of Biotin-PEG conjugates considerably. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-(acid-PEG3)-N-bis(PEG3-biotin) is a branched biotin linker that can be used for protein labeling. The carboxylic acid group can react with primary amines in the presence of activators such as EDC and HATU. The hydrophilic PEG branch increases the water solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

t-Boc-Aminooxy-PEG4-acid contains a Boc-protected aminooxy group and a terminal carboxylic acid. The terminal carboxylic acid (CO2H) is reactive with primary amine groups in the presence of EDC, to form a amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc-protected amine can be deprotected under mild acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

t-Boc-Aminooxy-PEG4-NHS ester is an active NHS ester which can react with amino(NH2)-containing molecule. The t-Boc can be removed under mild acidic condition to free the aminooxy group, which can react with aldehyde moiety.. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

4-Fluoro-thalidomide is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-(2,2,2-Trifluoroacetyl)-3-[(2-aminoethyl)dithio]propanoic acid is a cleavable linker containing a carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The disulfide bond can be cleaved via reduction reactions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.