Results for PEG ( 5993 )
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Hydroxy-PEG4-acid sodium salt is a PEG linker containing a hydroxyl group with a terminal carboxylic acid (as sodium salt form). The free acid form is not stable due to the reaction of OH with PEG-COOH group to form polymer. The sodium salt form is stable for storage and shipping. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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(S, R, S)-AHPC-PEG4-NHS ester is a PROTAC linker that incorporatess an E3 ligase ligand with a PEG4 spacer to empower PROTAC medicine chemistry. It is is reactive with amine molecule. PEG4 arm increases the molecule's solubility. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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(S, R, S)-AHPC-PEG2-NHS ester is a synthetic PROTAC linker that incorporatess an E3 ligase ligand with a PEG linker to empower PROTAC medicine chemistry. NHS ester is reactive with amine moiety. The hydrophilic PEG spacer increases its aqueous solubility. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Mal-amido-PEG5-alkyne is a PEG linker containing a maleimide group and an alkyne. The hydrophilic PEG spacer increases solubility in aqueous media. The alkyne group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Methyltetrazine-PEG4-t-butyl ester is PEG linker containing methyltetrazine and t-butyl ester moieties. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene). The t-butyl protected carboxyl group can be deprotected under acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.