PEG

PEG dimaleimide, Mp 2000

Fmoc-NH-PEG3-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-Sulfo-NHS ester is a water-soluble sulfocated reagent containing DBCO moiety. It can be used for simple and efficient labeling of antibodies, proteins and any other primary amine-bearing macromolecules with DBCO moiety in 100% aqueous buffers. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

TCO-Amine is a click chemistry building block containing a TCO moiety and a free amine. Amine is very reactive with active NHS ester or conjugate with carboxylic acid in the presence of of activators suh as EDC. The low mass weight will add minimal spacer to modified molecules. TCO moiety is very reactive with tetrazine ( 3rd generation click chemistry). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

t-Boc-N-amido-PEG-CH2COOH, MW 3,400 is a boc-protected PEG-based polymer. Carboxyl can react with primary amine (in the presence of EDC or HATU) via formation of a stable amide bond. The t-Boc can be removed under acidic condition to produce a free amine. Reagent grade, for research purpose.

t-Boc-N-amido-PEG-CH2COOH, MW 2,000 is a t-boc protected PEG reagent with terminal carboxylic acid. Coupling between carboxylic acid (-COOH) and an amine (-NH2) can be done in the presence of activator, such as HATU or EDC, to form a stable amide linkage.The t-boc protecting group can be removed using HCl or TFA to generate a free amine. Reagent grade, for research purpose.

5-azidopentanoic acid

Amino-PEG20-t-butyl ester is a long chain PEG linker containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG12-Maleimide is a PEG linker containing a DBCO moiety and a terminal primary maleimide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.