PEG

Biotin-PEG3-PC-methyltetrazine serves as a photocleavable, PEG linker comprised of a terminal biotin group that can react with amine molecules in the presence of activators such as EDC or HATU. The methyltetrazine group is TCO-reactive and can be employed to convert azido-bearing peptides or proteins into tetrazine-modified peptides or proteins without catalysts or axillary reagents. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp.

A methoxy-terminated PEG5000 functionalized with 1,2-distearoyl-sn-glycerol via an ether linkage. This compound may be used in the formulation of lipid nanoparticles (LNP's) for delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Sulfo-NHS-Acetate, free acid is a water-soluble acylating agent used in protein crosslinking reactions to prevent polymerization. It is also employed to inhibit polymerization when conjugating hapten peptides to carrier proteins for immunogen production.

Bis-propargyl-PEG, MW 20,000 is a crosslinking polyPEG reagent containing two propargyl groups, which enable the formation of triazole linkages with azide-bearing molecules in the presence of copper catalyst. The hydrophilicity of the molecule is improved because of the 20k polyPEG chain.

A bifunctional PEG1000 polymer chain featuring an "click chemistry" azido group and 14 carbon fatty acid tail on each end. This compound may be used for bioconjugation, surface modification, or as a novel component in lipid nanoparticle formulations for mRNA or drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade.

Methyltetrazine-PEG35-Iodoacetamido represents a special heterobifunctional PEG linker with methyltetrazine, which enables fast click reactions with TCO (trans-cycloctene), and iodoacetamide group, which is an alkylating agent that can be used to bind covalently with the thiol group. The lengthy PEG arm elevates the hydrophilicity of the molecule.

Nonadec-10-enenitrile

Azido-PEG-CH2CO2-NHS, MW 10,000 serves as a bifunctional polyPEG reagent with a terminal azide group which can perform copper-catalyzed Click Chemistry reactions with alkynes, DBCO, and BCN. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The 10k PEG units enhance the water-solubility of the molecule. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

PC Azido-PEG23-OH is a long, photocleavable PEG linker with an azido that can react with alkynes, DBCO, and BCN via copper-catalyzed Click Chemistry reactions. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp. The PEG polymer bolsters the hydrophilicity of the molecule. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.