PEG

NH2-PEG-acid, TFA salt, MW 5,000 constitutes a bifunctional PEG polymer consisting of a primary amine that is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses. The carboxylic acid can react with primary amine groups in the presence of activators such as HATU. The 5k polyPEG linking the two groups improves the solubility of the molecule in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 435 is an analog of the ionizable lipid LP01 and features a PEG6-azide linker for click chemistry, bioconjugation, or surface modification applications. This lipid may also be used as a novel component in lipid nanoparticle (LNP) formulations. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Pomalidomide-PEG8-propargyl serves as a PROTAC linker featuring a Pomalidomide-based cereblon ligand that incorporates an E3 ligase ligand. The terminal propargyl is reactive with azide-bearing compounds or biomolecules via copper-catalyzed azide-alkyne Click Chemistry. The PEG8 chain improves the water-solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DSPE-PEG-Gly-Gly-Gly TFA salt, MW 2,000 functions as an active ester reactive polyPEG phospholipid containing a Gly-Gly-Gly tripeptide which can be used for conjugation. The 2k PEG polymer greatly improves the water solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

PC Mal-PEG4-OH functions as a photocleavable PEG linker including a maleimide moiety which is thiol-reactive between pH 6.5 to 7.5. The PEG4 spacer increases the aqueous solubility of the compound and assists in fine-tuning DMPK properties. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

18-(Bromoacetamido-PEG6-ethylcarbamoyl)heptadecanoic acid

A cyclopropane fatty acid naturally found in bacterial cell membranes, seed oils, fermented foods, and dairy products. Studies suggest cyclopropane fatty acids are versatile cell membrane components that regulate membrane fluidity in response to environmental changes in pH and temperature (J. Phys. Chem. B 2015, 119, 17, 5487–5495) . Please contact us for the custom synthesis of any other cyclopropane fatty acids. Reagent grade, for research purpose. Please contact us for GMP-grade .

Mal-PEG4-Val-Cit-PAB-MMAF functions as a linker-payload construct with a thiol-specific maleimide which is used to label cysteine residues in proteins and an enzymatically cleavable Val-Cit site. The Val-Cit will specifically be cleaved by Cathepsin B. MMAF is a synthetic antineoplastic agent that may be employed as a cytotoxic payload. Solubility in aqueous media is enhanced via the PEG chain.

N-(Azide-PEG3)-PEG4-acid is a PEG linker composed of a terminal azide that undergoes click chemistry with linear alkynes, DBCO, and BCN, and a terminal carboxylic group that reacts with primary amine groups in the presence of activators (e.g. HATU).