PEG

BP Lipid 440 is an analog of the ionizable lipid LP01 whose key feature is the introduction of an iso- methyl branched fatty acid tail. This alteration has been designed to investigate the effect on the dynamics of lipid nanoparticle as methyl branched fatty acids have been reported to affect the fluidity and structure of lipid bilayers (J. Phys. Chem. B 2014, 118, 48, 13838–13848). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG10-amine constitutes a bifunctional PEG linker with DBCO and amine on either side, respectively. The DBCO group can be employed for copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The PEG spacer increases the solubility in aqueous media.

Oleyl Mesylate is a derivative of Oleyl Alcohol, commonly used in various formulations for delivery systems due to its functional properties. The mesyl group serves as a good leaving group for nucleophilic substitution reactions.

DBCO-PEG9-amine represents a bifunctional PEG linker with DBCO group for copper-free catalyzed click chemistry with azides and amine group for reacting with NHS-ester to form an amide bond.

DBCO-PEG-2-Val-Cit-PAB-PNP serves as a cleavable ADC linker derivative where PNP carbonate acts as a highly activated leaving group which may be used to react with amines. The Val-Cit dipeptide can be cleaved by Cathepsin B. The DBCO acts as a click chemistry handle that can react with azides without copper. Water solubility is enhanced via the PEG linker.

SPDP-PEG4-Azide is a PEG linker comprised of an SPDP crosslinker, which is reactive with thiol-containing molecules to form disulfide bonds, and an azide which reacts with DBCO, BCN, and linear alkynes through click chemistry.

Fluorescein-PEG7-Methyltetrazine is a xanthene dye with excitation/emission maximum of 494/517 nm and a terminal tetrazine group. The terminal methyltetrazine enables fast click reactions with TCO (trans-cycloctene). Hydrophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. Reagent grade, for research use only. Please contact us for GMP-grade inquiries.

Methyltetrazine-PEG4-PFP ester operates as a heterobifunctional PEG linker including methyltetrazine, a click chemistry handle used to efficiently react with trans-cyclooctenes (TCO), and PFP ester, an amine-reactive ester that is less susceptible toward hydrolysis compared to NHS ester. The hydrophilicity of the molecule is elevated via the PEG4 spacer.

DBCO-PEG8-amine represents a PEG linker with an azide-reactive DBCO group that participates in copper-free catalyzed chemistry and amine that can be used to derivatize carboxyl groups via activators (e.g. HATU) or NHS ester groups directly.