Cytokines & Chemokines

Recombinant Rat SDF-1beta (CXCL12) (Legacy Tebubio ref. 167400-32B). SDF-1alpha and beta are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1alpha and beta chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1alpha and beta contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1beta protein, produced by an N-terminal truncation of two additional amino acids, after removal of the signal sequence, contains 72 amino acid residues. Recombinant Rat SDF-1beta is an 8.4 kDa protein containing 72 amino acid residues.

Recombinant Rat SDF-1beta (CXCL12) (Legacy Tebubio ref. 167400-32B). SDF-1alpha and beta are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1alpha and beta chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1alpha and beta contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1beta protein, produced by an N-terminal truncation of two additional amino acids, after removal of the signal sequence, contains 72 amino acid residues. Recombinant Rat SDF-1beta is an 8.4 kDa protein containing 72 amino acid residues.

Recombinant Rat IP-10 (CXCL10) (Legacy Tebubio ref. 167400-33). IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant Rat IP-10 is an 8.6 kDa protein consisting of 77 amino acids, including the four conserved cysteine residues present in CXC chemokines.

Recombinant Rat IP-10 (CXCL10) (Legacy Tebubio ref. 167400-33). IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant Rat IP-10 is an 8.6 kDa protein consisting of 77 amino acids, including the four conserved cysteine residues present in CXC chemokines.

Recombinant Rat Resistin (Legacy Tebubio ref. 167400-35). Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The four known members of this family, resistin, RELMalpha, RELMbeta, and RELMgamma, share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that resistin expression is severely suppressed in obesity, and that it may act as a feedback regulator of Adipogenesis. Recombinant Rat Resistin is a 20.0 kDa, disulfide-linked, homodimeric protein composed of two 94 identical amino acid chains linked

Recombinant Rat Resistin (Legacy Tebubio ref. 167400-35). Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The four known members of this family, resistin, RELMalpha, RELMbeta, and RELMgamma, share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that resistin expression is severely suppressed in obesity, and that it may act as a feedback regulator of Adipogenesis. Recombinant Rat Resistin is a 20.0 kDa, disulfide-linked, homodimeric protein composed of two 94 identical amino acid chains linked

Recombinant Rat Oncostatin M (Legacy Tebubio ref. 167400-36). Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF. Recombinant Rat Oncostatin M is a 24.4 kDa protein, containing 215 amino acid residues.

Recombinant Rat Oncostatin M (Legacy Tebubio ref. 167400-36). Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF. Recombinant Rat Oncostatin M is a 24.4 kDa protein, containing 215 amino acid residues.

Recombinant Rat IL-21 (Legacy Tebubio ref. 167400-41). IL‐21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen‐specific responses of immune cells. The biological effects of IL‐21 include: inducing the differentiation of T cell‐stimulated B cells into plasma cells and memory B cells; the stimulation of IgG production in conjunction with IL‐4; and the induction of apoptotic effects in naïve B cells and stimulated B cells in the absence of T cell signaling. Additionally, IL‐21 promotes the anti‐tumor activity of CD8+ T cells and NK cells. IL‐21 exerts its effect through binding to a specific type I cytokine receptor, IL‐21R, which also contains the γ chain (γc) found in other cytokine receptors, including IL‐2, IL‐4, IL‐7, IL‐9 and IL‐15. The IL‐21/IL‐21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors S